The kinetics of Torque Teno virus plasma load following calcineurin inhibitor dose change in kidney transplant recipients.
Torque Teno virus
calcineurin inhibitor
immunologic monitoring
kidney transplantation
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
02
02
2024
received:
21
11
2023
accepted:
10
03
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
ppublish
Résumé
Torque Teno virus (TTV) is nonpathogenic, highly prevalent, and reflects the immune status of its host. Thus, TTV plasma load was suggested for the guidance of immunosuppression post solid organ transplantation. The present study was designed to determine the kinetics of TTV following changes in calcineurin inhibitor (CNI) dose. A total of 48 adult recipients of a kidney graft transplanted at the Medical University of Vienna between 2018 and 2019 with isolated changes in CNI dose were selected from the prospective TTV-POET trial. TTV plasma load was quantified by in-house PCR. At Day 30 following CNI dose adaptation (median 33% of daily dose) no changes in TTV load were noted. However, at Day 60, following CNI dose reduction a lower TTV load of 6.4 log
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29554Subventions
Organisme : Horizon 2020 Framework Program
Informations de copyright
© 2024 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
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