The S-REAL study: Spanish real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy.

Chemoradiotherapy Durvalumab NSCLC PD-L1 PFS Real-world

Journal

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119

Informations de publication

Date de publication:
21 Mar 2024
Historique:
received: 08 11 2023
accepted: 01 02 2024
medline: 21 3 2024
pubmed: 21 3 2024
entrez: 21 3 2024
Statut: aheadofprint

Résumé

The S-REAL study aimed to assess the effectiveness of durvalumab as consolidation therapy after definitive chemoradiotherapy (CRT) in a real-world cohort of patients with locally advanced, unresectable stage III non-small cell lung cancer (LA-NSCLC) included in a Spanish early access program (EAP). In this multicentre, observational, retrospective study we analysed data from patients treated in 39 Spanish hospitals, who started intravenous durvalumab (10 mg/kg every 2 weeks) between September 2017 and December 2018. The primary endpoint was progression-free survival (PFS). Secondary endpoints included patient characterization and adverse events of special interest (AESI). A total of 244 patients were followed up for a median of 21.9 months [range 1.2-34.7]. Median duration of durvalumab was 45.5 weeks (11.4 months) [0-145]. Median PFS was 16.7 months (95% CI 12.2-25). No remarkable differences in PFS were observed between patients with programmed cell death-ligand 1 (PD-L1) expression ≥ 1% or < 1% (16.7 versus 15.6 months, respectively). However, PFS was higher in patients who had received prior concurrent CRT (cCRT) versus sequential CRT (sCRT) (20.6 versus 9.4 months). AESIs leading to durvalumab discontinuation were registered in 11.1% of patients. These results are in line with prior published evidence and confirm the benefits of durvalumab in the treatment of LA-NSCLC patients in a real-world setting. We also observed a lower incidence of important treatment-associated toxicities, such as pneumonitis, compared with the pivotal phase III PACIFIC clinical study.

Identifiants

pubmed: 38512450
doi: 10.1007/s12094-024-03404-9
pii: 10.1007/s12094-024-03404-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).

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Auteurs

Ana Gómez Rueda (A)

Medical Oncology Department, IRYCIS, Hospital Universitario Ramón y Cajal, Carretera Colmenar ViejoKM 9100, 28034, Madrid, Spain.

Álvaro Taus (Á)

Medical Oncology Department, Hospital del Mar, Barcelona, Spain.

Rosa Álvarez Álvarez (R)

Medical Oncology Department, Hospital Universitario Gregorio Marañón, Madrid, Spain.

Reyes Bernabé-Caro (R)

Medical Oncology Department, Hospital Virgen del Rocío, Seville, Spain.

Luis Chara (L)

Medical Oncology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Marta López-Brea (M)

Medical Oncology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Laia Vilà (L)

Medical Oncology Department, Hospital Universitario Parc Taulí, Institut d'Investigació I Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.

Maria Ángeles Sala González (MÁ)

OSI Bilbao Basurto, Bibao, Spain.

Anabel Del Barrio Díaz Aldagalán (A)

HM Sanchinarro, Madrid, Spain.

Beatriz Esteban Herrera (B)

Hospital General de Segovia, Segovia, Spain.

Rafael López Castro (R)

Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Ruth Álvarez Cabellos (R)

Medical Oncology Service, Hospital Universitario de Toledo, Toledo, Spain.

Marta Doménech (M)

Medical Oncology Department, Instituto Catalán de Oncología, Badalona, Spain.
Hospital Germans Trias i Pujol, Barcelona, Spain.

Sandra Falagan (S)

Hospital Universitario Infanta Sofía, Madrid, Spain.

Alberto Moreno Vega (A)

Hospital Universitario Reina Sofía, Córdoba, Spain.

Carlos Aguado (C)

Medical Oncology Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.

Andrés Barba (A)

Medical Oncology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.

Maria Teresa Delgado Ureña (MT)

Medical Oncology Department, Hospital Clínico San Cecilio, Granada, Spain.

Dolores Isla (D)

Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.

Lorena Bellido Hernández (L)

Medical Oncology Department, Hospital Universitario de Salamanca, Salamanca, Spain.

José Luis Fírvida Pérez (JL)

Complejo Hospitalario Universitario de Ourense, Ourense, Spain.

Óscar Juan-Vidal (Ó)

Medical Oncology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Bartomeu Massutí (B)

Medical Oncology Department, Hospital Universitario de Alicante-ISABIAL, Alicante, Spain.

Xabier Mielgo-Rubio (X)

Medical Oncology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Ana Laura Ortega (AL)

UGC de Oncología Médica, Hospital Universitario de Jaén, Jaén, Spain.

Silvia Catot (S)

Medical Oncology Department Althaia, Xarxa Assistencial Universitària Manresa, Barcelona, Spain.

Manuel Dómine (M)

Hospital Universitario Fundación Jiménez Díaz, IIS-FJD, Madrid, Spain.

Corina Escoín-Pérez (C)

Medical Oncology Department, Hospital Universitario de La Ribera, Valencia, Spain.

Francisco García Navalón (F)

Medical Oncology Department, Hospital Universitario Son Llatzer, Mallorca, Spain.

Ignacio Gil-Bazo (I)

Medical Oncology Department, Clínica Universidad de Navarra, Pamplona, Spain.
Fundación Instituto Valenciano de Oncología, Valencia, CIBERONC, Madrid, Spain.

Silvia Muñoz (S)

Medical Oncology Department, Hospital General de Granollers, Barcelona, Spain.

Delvys Rodríguez-Abreu (D)

Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

Rosa María Villatoro Roldán (RM)

Medical Oncology Department, Hospital Costa del Sol, Málaga, Spain.

Guillermo Alonso-Jáudenes Curbera (G)

Medical Oncology Department, Complejo Hospitalario Universitario de A Coruña, Coruña, Spain.

Luis León-Mateos (L)

Medical Oncology Department, Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.

Airam Padilla (A)

Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.

Alfredo Paredes Lario (A)

Department of Medical Oncology, Hospital Universitario de Donostia, San Sebastián, Spain.

José Miguel Sánchez-Torres (JM)

Department of Medical Oncology, Hospital Universitario la Princesa, Madrid, Spain.

Pilar Garrido (P)

Medical Oncology Department, IRYCIS, Hospital Universitario Ramón y Cajal, Carretera Colmenar ViejoKM 9100, 28034, Madrid, Spain. pilargarridol@gmail.com.

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