The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.
Antibiotics
Biosynthesis
P450 Enzymes
Polyketides
Structure Elucidation
Journal
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
ISSN: 0044-8249
Titre abrégé: Angew Chem Weinheim Bergstr Ger
Pays: Germany
ID NLM: 100955692
Informations de publication
Date de publication:
16 Jan 2023
16 Jan 2023
Historique:
received:
05
09
2022
medline:
16
1
2023
pubmed:
16
1
2023
entrez:
22
3
2024
Statut:
ppublish
Résumé
Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using a combination of synthesis and in vitro assays we reveal that AbyV, a cytochrome P450 enzyme from the The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a
Autres résumés
Type: Publisher
(ger)
The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a
Identifiants
pubmed: 38516347
doi: 10.1002/ange.202213053
pii: ANGE202213053
pmc: PMC10952897
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e202213053Informations de copyright
© 2022 The Authors. Angewandte Chemie published by Wiley-VCH GmbH.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.