Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.
C−H Functionalization
Nucleic Acids
Photocatalysis
Radicals
Reaction Mechanisms
Journal
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
ISSN: 0044-8249
Titre abrégé: Angew Chem Weinheim Bergstr Ger
Pays: Germany
ID NLM: 100955692
Informations de publication
Date de publication:
26 Jun 2023
26 Jun 2023
Historique:
received:
04
04
2023
medline:
22
3
2024
pubmed:
22
3
2024
entrez:
22
3
2024
Statut:
ppublish
Résumé
The epigenetic modification 5-methylcytosine plays a vital role in development, cell specific gene expression and disease states. The selective chemical modification of the 5-methylcytosine methyl group is challenging. Currently, no such chemistry exists. Direct functionalisation of 5-methylcytosine would improve the detection and study of this epigenetic feature. We report a xanthone-photosensitised process that introduces a 4-pyridine modification at a C(sp Selective functionalisation of the C(sp
Autres résumés
Type: Publisher
(ger)
Selective functionalisation of the C(sp
Identifiants
pubmed: 38516645
doi: 10.1002/ange.202304756
pii: ANGE202304756
pmc: PMC10953388
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e202304756Informations de copyright
© 2023 The Authors. Angewandte Chemie published by Wiley-VCH GmbH.
Déclaration de conflit d'intérêts
S.B. is an advisor and shareholder of Biomodal Ltd. (formerly called Cambridge Epigenetix Ltd.), Inflex Ltd. and Elyx Ltd. A patent application has been filed based on some of the work described in this manuscript.