Interventions for Pancreatitis-New Approaches, Knowledge Gaps, and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Journal
Pancreas
ISSN: 1536-4828
Titre abrégé: Pancreas
Pays: United States
ID NLM: 8608542
Informations de publication
Date de publication:
01 Apr 2024
01 Apr 2024
Historique:
medline:
22
3
2024
pubmed:
22
3
2024
entrez:
22
3
2024
Statut:
ppublish
Résumé
There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on interventions that might disrupt or perhaps even reverse the natural course of this heterogenous disease, aiming to identify knowledge gaps and research opportunities that might inform future funding initiatives for NIDDK. The breadth and variety of identified active or planned clinical trials traverses the spectrum of the disease and was conceptually grouped for the workshop into behavioral, nutritional, pharmacologic and biologic, and mechanical interventions. Cognitive and other behavioral therapies are proven interventions for pain and addiction, but barriers exist to their use. Whilst a disease specific instrument quantifying pain is now validated, an equivalent is lacking for nutrition - and both face challenges in ease and frequency of administration. Multiple pharmacologic agents hold promise. Ongoing development of Patient Reported Outcome (PRO) measurements can satisfy Investigative New Drug (IND) regulatory assessments. Despite multiple randomized clinical trials demonstrating benefit, great uncertainty remains regarding patient selection, timing of intervention, and type of mechanical intervention (endoscopic versus surgery). Challenges and opportunities to establish beneficial interventions for patients were identified.
Identifiants
pubmed: 38518063
doi: 10.1097/MPA.0000000000002333
pii: 00006676-202404000-00010
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e368-e377Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
All other authors report no relevant financial or other conflicts of interest. Disclosures: The following authors disclose potential conflicts of interest: A.E.P. (board member, National Pancreas Foundation), R.B. (board member, National Pancreas Foundation), G.C. (consultant, Olympus America; consultant, Interpace Diagnostics; scientific advisory board, Genprex), S.D. (corecipient of unrestricted industry research funding from Mylan Healthcare, expert panel for Mylan Healthcare), A.F. (consultant work for Takeda and Abbvie), C.F. (board member, National Pancreas Foundation; research support, Abbvie), M.R. (honoraria from Fresenius Kabi as speaker); V.S. (board member, National Panreas Foundation; consultant to Abbvie, Ariel Precision Medicine, Organon, Nestle Health Sciences, Panafina, and Horizon Therapeutics; scientific advisory board member and equity holder in Kyttaro and Origin Endoscopy), D.W. (consultant to Abbvie, Ariel Precision Medicine, Nestle, Organon, Regeneron; cofounder and chief scientific officer, Ariel Precision Medicine), and D.Y. (consultant, Pfizer Inc).
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