Lactobacillus casei Shirota probiotic drinks reduce antibiotic associated diarrhoea in patients with spinal cord injuries who regularly consume proton pump inhibitors: a subgroup analysis of the ECLISP multicentre RCT.
Journal
Spinal cord
ISSN: 1476-5624
Titre abrégé: Spinal Cord
Pays: England
ID NLM: 9609749
Informations de publication
Date de publication:
22 Mar 2024
22 Mar 2024
Historique:
received:
13
06
2023
accepted:
13
03
2024
revised:
08
03
2024
medline:
23
3
2024
pubmed:
23
3
2024
entrez:
23
3
2024
Statut:
aheadofprint
Résumé
This was a sub-group analysis of a multicentre, randomised, placebo-controlled, double-blind trial (ECLISP trial) OBJECTIVES: To assess the efficacy of a probiotic containing at least 6.5 × 10 Three SCI centres (National Spinal Injuries Centre, Midland Centre for Spinal Injuries and Princess Royal Spinal Cord Injuries Centre) in the United Kingdom METHODS: Between November 2014, and November 2019, 95 eligible consenting SCI patients (median age: 57; IQ range: 43-69) were randomly allocated to receive LcS (n = 50) or placebo (n = 45). The primary outcome is the occurrence of AAD up to 30 days after finishing LcS/placebo. The LcS group had a significantly lower incidence of AAD at 30 days after finishing the antibiotic course (28.0 v 53.3%, RR: 95% CI: 0.53, 0.31-0.89; z = 2.5, p = 0.01). Multivariate logistic regression analysis identified that LcS can reduce the risk of AAD at 30 days (OR: 0.36, 95% CI 0.13, 0.99, p < 0.05). No intervention-related adverse events were reported during the study. LcS has the potential to prevent AAD in what could be considered a defined vulnerable group of SCI patients on regular PPI. A confirmatory, randomised, placebo-controlled study is needed to confirm this apparent therapeutic success to translate it into appropriate clinical outcomes. Yakult Honsha Co., Ltd.
Identifiants
pubmed: 38519563
doi: 10.1038/s41393-024-00983-w
pii: 10.1038/s41393-024-00983-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Crown.
Références
Spinal cord injury paralyses someone every four hours, new estimates reveal. Spinal Injury Association. 2022. https://www.spinal.co.uk/news/spinal-cord-injury-paralyses-someone-every-four-hours-new-estimates-reveal/ . Accessed 16
Wong S, Santullo P, Hirani SP, Kumar N, Chowdhury JR, Carcia-Forcada A, et al. Use of antibiotic and the prevalence of antibiotic-associated dirrhoea in patients with spinal cord injuries: an international, multi-centre study. J Hosp Infect. 2017;97:146–52.
doi: 10.1016/j.jhin.2017.06.019
pubmed: 28647425
Vigil HR, Hickling DR. Urinary tract infection in the neurogenic bladder. Transl Androl Urol. 2016;5:72–87.
pubmed: 26904414
pmcid: 4739987
Meddings J, Rogers MAM, Macy M, Saint S. Systematic review and meta-analysis: reminder system to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients. Clin Infect Dis. 2010;51:550–60.
doi: 10.1086/655133
pubmed: 20673003
Janarthanan S, Ditah, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol. 2012;107:1001–10.
doi: 10.1038/ajg.2012.179
pubmed: 22710578
Wong S, Jamous A, O’Driscoll J, Sekhar R, Weldon M, Yau C, et al. A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial. Br J Nutr. 2014;111:672–8.
doi: 10.1017/S0007114513002973
pubmed: 24044687
Wong S, Santullo P, O’Driscoll J, Jamous A, Hirani SP, Saif M. Use of antibiotic and prevalence of antibiotic-associated diarrhoea in patients with spinal cord injuries: a UK national spinal injury centre experience. Spinal Cord. 2017;55:483–587.
doi: 10.1038/sc.2016.193
Wong S, Santullo P, Hirani SP, Kumar N, Chowdhury JR, Gracia-Forcada A, et al. Use of antibiotics and the prevalence of antibiotic-associated diarrhoea in patients with spinal cord injuries: an international, multi-centre study. J Hosp Infect. 2017;97:146–52.
doi: 10.1016/j.jhin.2017.06.019
pubmed: 28647425
Wong S, Hirani SP, Forbes A, Kumar N, Hariharan R, O’Driscoll J, et al. A study into the effect of Lactobacillus casei Shirota in preventing antibiotic associated diarrhoea including Clostridioides difficile infection in patients with spinal cord injuries: a multicentre randomised, double-blind, placebo-controlled trial. EClinicalmedicine. 2021;40:101098. https://doi.org/10.1016/j.eclinm.2021.101098 .
doi: 10.1016/j.eclinm.2021.101098
pubmed: 34541475
pmcid: 8435694
National Institute for Health and Care Excellence. Clostridium difficile infection: risk with broad-spectrum antibiotics. Evidence summary. 2015. https://www.nice.org.uk/advice/esmpb1/chapter/Key-points-from-the-evidence . Accessed 20th June 2020.
American Spinal Injury Association. International standards for neurological classification of spinal cord injury. Richmond (VA): American Spinal Injury Association; 2019.
Kelly CP, LaMont JT. Clostridium difficile infection. Annu Rev Med. 1998;49:375–90.
doi: 10.1146/annurev.med.49.1.375
pubmed: 9509270
O’Donnell LD, Virjee J, Heaton KW. Detection of pseudo diarrhoea by simple clinical assessment of intestinal transit time. Br Med J. 1990;300:439–40.
doi: 10.1136/bmj.300.6722.439
Wong S, Saif M, O’Driscoll J, Sekhar R, Saif M, O’Driscoll S, et al. Use of probiotic in preventing antibiotic associated diarrhoea and Clostridium difficile associated diarrhoea in spinal injury centres: an international multicentre survey. Int J Probiotics Prebiotics. 2015;10:85–90.
Rubin D. Multiple imputation for nonresponse in surveys. John Wiley & Sons, InC, New York, 1987.
Schafer JL, Olsen MK. Multiple Imputation for Multivariate Missing-Data Problems: A Data Analyst’s Perspective. Multivar Behav Res. 1998;33:545–71. https://doi.org/10.1207/s15327906mbr3304_5 .
doi: 10.1207/s15327906mbr3304_5
Wong S, Derry F, Jamous A, Hirani SP, Grimble G, Forbes A. Validation of the Spinal Nutrition Screening Tool (SNST) in patients with spinal cord injuries (SCI) – result from a multicentre study. Eur J Clin Nutr. 2012;66:382–7.
doi: 10.1038/ejcn.2011.209
pubmed: 22166898
NHS England. NHS Five Year Forward View. 2017. https://www.england.nhs.uk/five-year-forward-view/ . Accessed 30
Van Middendorp J, Allison H, Cowan K, for the Spinal Cord Injury Priority Setting Partnership. Top ten research priorities for spinal cord injury. Lancet Neurol. 2014;13:1167.
doi: 10.1016/S1474-4422(14)70253-4
pubmed: 25453451
Rajkumar C, Wilks M, Islam J, Ali K, Rafterj J, Davies KA, et al. Do probiotics prevent antibiotic-associated diarrhoea? Results of a multicentre randomized placebo-controlled trial. J Hosp Infect. 2020;105:280–8.
doi: 10.1016/j.jhin.2020.01.018
pubmed: 32035998
Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-assocaited diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2013;382:1249–57.
doi: 10.1016/S0140-6736(13)61218-0
pubmed: 23932219
McFarland LV. Update on the changing epidemiology of Clostridium difficile-associated disease. Nat Clin Pr Gastroenterol Hepatol. 2008;5:40–48.
doi: 10.1038/ncpgasthep1029
Helps A, Bell E, Mactier R. Prospective randomized dibble-blind study of efficacy of probiotic milk drink in reducing the incidence of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea. Int J Probiotic Prebiotics. 2015;4:145–52.
Johnston BC, Lytvyn L, Ka-Fung C, Allen S, Wang D, Szajewska H, et al. Clostridium difficile Infection in Adults and Children: An individual patient data meta-analysis of 6,851 participants. Infect Control Hosp Epidemiol. 2018;39:771–81.
doi: 10.1017/ice.2018.84
pubmed: 29695312
Matsuzaki T, Saito M, Usuku K, Nose H, Izumo S, Arimura K, et al. A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy / tropical spastic paraparesis. J Neuro Sci. 2005;237:75–81.
doi: 10.1016/j.jns.2005.05.011
Stadlbauer V, Moorkerjee RP, Hodges SJ, Wright GA, Davies N, Jalan R. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol. 2006;48:945–51.
doi: 10.1016/j.jhep.2008.02.015
Selinger C, Bell A, Cairns A, Lockett M, Sebastian S, Halasm N. Probiotic VSL#3 prevent antibiotic-associated diarrhoea in a double-blind, randomized, placebo-controlled clinical trial. J Hosp Infect. 2013;84:159–65.
doi: 10.1016/j.jhin.2013.02.019
pubmed: 23618760
McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhoea and the treatment of Clostridium difficile diseases. Am J Gastroenterol. 2006;101:812–22.
doi: 10.1111/j.1572-0241.2006.00465.x
pubmed: 16635227
Yuki N, Watanabe K, Miller A, Tagami Y, Tanaka R, Ohwaki M, et al. Survival of a probiotic, Lactobacillus casei strain Shirota, in the gastrointestinal tract: selective isolation from faeces and identification using monoclonal antibodies. Int J Food Microbiol. 1999;48:51–57.
doi: 10.1016/S0168-1605(99)00029-X
pubmed: 10375134
Khine WWT, Ang XJ, Chang YS, Lee WQ, Quek SY, Tan SH, et al. Recovery of Lactobacillus casei strain Shirota (LcS) from faeces of healthy Singapore adults after intake of fermented milk. Beneficial Microbes. 2019;10:721–8.
doi: 10.3920/BM2018.0173
pubmed: 31965844