COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?
asthma
preschool
school‐age
sensitization
severe asthma
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
05
03
2024
received:
04
09
2023
accepted:
06
03
2024
medline:
23
3
2024
pubmed:
23
3
2024
entrez:
23
3
2024
Statut:
ppublish
Résumé
It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA. IgE to 112 components (c-sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3-6 years) and 170 school-age children (7-12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c-sIgE. We observed c-sIgE sensitization in 51% of preschool and 75% of school-age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p < .01). Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p < .01) and associated with an FEV1/FVC < -1.64 z-score. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by "few sensitizations, mainly to HDM." One cluster (n = 4) with "multiple sensitizations, mainly to grass pollen, HDM, PR-10, and nsLTP" was associated with SA in school-age children. Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.
Sections du résumé
BACKGROUND
BACKGROUND
It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA.
METHODS
METHODS
IgE to 112 components (c-sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3-6 years) and 170 school-age children (7-12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c-sIgE.
RESULTS
RESULTS
We observed c-sIgE sensitization in 51% of preschool and 75% of school-age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p < .01). Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p < .01) and associated with an FEV1/FVC < -1.64 z-score. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by "few sensitizations, mainly to HDM." One cluster (n = 4) with "multiple sensitizations, mainly to grass pollen, HDM, PR-10, and nsLTP" was associated with SA in school-age children.
CONCLUSIONS
CONCLUSIONS
Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14112Subventions
Organisme : Chiesi Foundation
Organisme : Novartis
Organisme : Mundipharma Pharmaceuticals srl
Organisme : Stallergènes
Organisme : GlaxoSmithKline Foundation
Organisme : Chancellerie des Universités de Paris (legs Gaston Poix)
Investigateurs
Rola Abou-Taam
(R)
Muriel Le Bourgeois
(M)
Alice Hadchouel-Duvergé
(A)
David Drummond
(D)
Christophe Delacourt
(C)
Marie-Alexandra Alyanakian
(MA)
Lucienne Chatennoud
(L)
Caroline Thumerelle
(C)
Clémence Mordacq
(C)
Irina Badiu-Decleyre
(I)
Cécile Bonnel
(C)
Laure Delbecque
(L)
Laurent Beghin
(L)
Graziella Mingardi
(G)
Caroline Tournegros
(C)
Sylvain Blanchon
(S)
Léa Roditis
(L)
Véronique Houdoin
(V)
Stéphanie Wanin
(S)
Marie Noelle Lebras
(MN)
Stéphane Debelleix
(S)
Valérie Siao
(V)
Marine Servat
(M)
Guillaume Simon
(G)
Patricia El Boustany
(P)
Emmanuelle Bosdure
(E)
Julie Mazenq
(J)
Isabelle Cabon
(I)
Camille Ohlmann
(C)
Stéphanie Vrielynck
(S)
Virginie Jubin
(V)
Sylvie-Anne André Gomez
(SA)
Marie-Christine Werck Gallois
(MW)
Priscille Biermé
(P)
Isabelle Pin
(I)
Sylvie Chollet-Martin
(S)
Informations de copyright
© 2024 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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