COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

asthma preschool school‐age sensitization severe asthma

Journal

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718

Informations de publication

Date de publication:
Mar 2024
Historique:
revised: 05 03 2024
received: 04 09 2023
accepted: 06 03 2024
medline: 23 3 2024
pubmed: 23 3 2024
entrez: 23 3 2024
Statut: ppublish

Résumé

It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA. IgE to 112 components (c-sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3-6 years) and 170 school-age children (7-12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c-sIgE. We observed c-sIgE sensitization in 51% of preschool and 75% of school-age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p < .01). Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p < .01) and associated with an FEV1/FVC < -1.64 z-score. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by "few sensitizations, mainly to HDM." One cluster (n = 4) with "multiple sensitizations, mainly to grass pollen, HDM, PR-10, and nsLTP" was associated with SA in school-age children. Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.

Sections du résumé

BACKGROUND BACKGROUND
It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA.
METHODS METHODS
IgE to 112 components (c-sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3-6 years) and 170 school-age children (7-12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c-sIgE.
RESULTS RESULTS
We observed c-sIgE sensitization in 51% of preschool and 75% of school-age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p < .01). Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p < .01) and associated with an FEV1/FVC < -1.64 z-score. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by "few sensitizations, mainly to HDM." One cluster (n = 4) with "multiple sensitizations, mainly to grass pollen, HDM, PR-10, and nsLTP" was associated with SA in school-age children.
CONCLUSIONS CONCLUSIONS
Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.

Identifiants

pubmed: 38520021
doi: 10.1111/pai.14112
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14112

Subventions

Organisme : Chiesi Foundation
Organisme : Novartis
Organisme : Mundipharma Pharmaceuticals srl
Organisme : Stallergènes
Organisme : GlaxoSmithKline Foundation
Organisme : Chancellerie des Universités de Paris (legs Gaston Poix)

Investigateurs

Rola Abou-Taam (R)
Muriel Le Bourgeois (M)
Alice Hadchouel-Duvergé (A)
David Drummond (D)
Christophe Delacourt (C)
Marie-Alexandra Alyanakian (MA)
Lucienne Chatennoud (L)
Caroline Thumerelle (C)
Clémence Mordacq (C)
Irina Badiu-Decleyre (I)
Cécile Bonnel (C)
Laure Delbecque (L)
Laurent Beghin (L)
Graziella Mingardi (G)
Caroline Tournegros (C)
Sylvain Blanchon (S)
Léa Roditis (L)
Véronique Houdoin (V)
Stéphanie Wanin (S)
Marie Noelle Lebras (MN)
Stéphane Debelleix (S)
Valérie Siao (V)
Marine Servat (M)
Guillaume Simon (G)
Patricia El Boustany (P)
Emmanuelle Bosdure (E)
Julie Mazenq (J)
Isabelle Cabon (I)
Camille Ohlmann (C)
Stéphanie Vrielynck (S)
Virginie Jubin (V)
Sylvie-Anne André Gomez (SA)
Marie-Christine Werck Gallois (MW)
Priscille Biermé (P)
Isabelle Pin (I)
Sylvie Chollet-Martin (S)

Informations de copyright

© 2024 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Auteurs

Stéphanie Lejeune (S)

Pediatric Pulmonology and Allergy Department, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Hôpital Jeanne de Flandre, Univ. Lille, Lille, France.
Clinical Investigation Center, LIRIC UMR 995 Inserm, CIC-1403-Inserm-CHU, Univ. Lille, Lille, France.

Naïm Bouazza (N)

Unité de Recherche Clinique-Centre Investigation Clinique, APHP, Hôpital Necker-Enfants malades, Paris, France.

Pascale Roland Nicaise (PR)

Immunology Department, Hôpital Bichat, APHP, Paris, France.
Inserm, PHERE, Université Paris Cité, Paris, France.

Valérie Jolaine (V)

Unité de Recherche Clinique-Centre Investigation Clinique, APHP, Hôpital Necker-Enfants malades, Paris, France.

Léa Roditis (L)

Pediatric Pulmonology and Allergology Unit CHU Toulouse, Children Hospital, Toulouse, France.

Christophe Marguet (C)

Pediatric Respiratory and Allergic Diseases, CF Reference Center, Rouen University Hospital-Charles Nicolle, EA3830-GHRV, Rouen University, Rouen, France.

Flore Amat (F)

Pediatric Pulmonology and Allergology, INSERM UMR 1018, Robert Debré Hospital, University of Paris Cité, Paris, France.

Patrick Berger (P)

Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM, U1045, Centre d'Investigation Clinique (CIC 1401), Univ. Bordeaux, Bordeaux, France.

Michael Fayon (M)

Unité de Pneumologie Pédiatrique, Centre d'Investigation Clinique (CIC 1401), CHU de Bordeaux, Bordeaux, France.

Jean-Christophe Dubus (JC)

Unité de Pneumopédiatrie CHU Timone-Enfants, Aix-Marseille Université, IRD MEPHI, IHU Méditerranée-Infection, Marseille, France.

Sophie Valois (S)

Pédiatrie, CHU Grenoble Alpes, INSERM, Institute for Advanced Biosciences, Université Grenoble Alpes, Grenoble, France.

Philippe Reix (P)

Service de Pneumologie, Allergologie et Mucoviscidose Pédiatrique, CHU de Lyon, Lyon, France.
UMR 5558 (EMET), CNRS, LBBE, Université de Lyon, Villeurbanne, France.

Mathieu Pellan (M)

Service de Pédiatrie, CHU Jean Verdier, Bondy, France.

Jacques Brouard (J)

Service de Pédiatrie Médicale, CHU Caen, Caen, France.
Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Normandie Université, Caen, France.

Raphael Chiron (R)

Pediatric Department, Montpellier University Hospital, Montpellier, France.

Lisa Giovannini-Chami (L)

Pediatric Pulmonology Department, Lenval University Hospital, Nice, France.

Jacques de Blic (J)

Department of Pediatric Pulmonology and Allergy, AP-HP, Hôpital Necker-Enfants Malades, Université Paris Cité, Paris, France.

Antoine Deschildre (A)

Pediatric Pulmonology and Allergy Department, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Hôpital Jeanne de Flandre, Univ. Lille, Lille, France.
Clinical Investigation Center, LIRIC UMR 995 Inserm, CIC-1403-Inserm-CHU, Univ. Lille, Lille, France.

Guillaume Lezmi (G)

Department of Pediatric Pulmonology and Allergy, AP-HP, Hôpital Necker-Enfants Malades, Université Paris Cité, Paris, France.

Classifications MeSH