Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells.

ATR DNA replication stress PROTAC cereblon leukemia

Journal

Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230

Informations de publication

Date de publication:
22 Mar 2024
Historique:
revised: 05 02 2024
received: 24 01 2024
accepted: 12 03 2024
medline: 23 3 2024
pubmed: 23 3 2024
entrez: 23 3 2024
Statut: aheadofprint

Résumé

Mammalian cells replicate ~ 3 × 10

Identifiants

pubmed: 38520049
doi: 10.1002/1878-0261.13638
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1361
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1292TP21N
Organisme : Deutsche Forschungsgemeinschaft
ID : KR2291
Organisme : Deutsche Forschungsgemeinschaft
ID : SI868/22-1
Organisme : German Academic Exchange service
Organisme : Walter Schulz-Stiftung
Organisme : Brigitte und Dr. Konstanze Wegener-Stiftung

Informations de copyright

© 2024 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

Références

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Mahajan K, Mahajan NP. Cross talk of tyrosine kinases with the DNA damage signaling pathways. Nucleic Acids Res. 2015;43(22):10588–10601.
Saldanha J, Rageul J, Patel JA, Kim H. The adaptive mechanisms and checkpoint responses to a stressed DNA replication fork. Int J Mol Sci. 2023;24(13):10488.
Lecona E, Fernandez‐Capetillo O. Targeting ATR in cancer. Nat Rev Cancer. 2018;18(9):586–595.
Mustafa AM, Krämer OH. Pharmacological modulation of the crosstalk between aberrant Janus kinase signaling and epigenetic modifiers of the histone deacetylase family to treat cancer. Pharmacol Rev. 2023;75(1):35–61.
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Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, et al. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase‐2A subunit PR130. Nat Commun. 2018;9(1):764.
Beyer M, Henninger SJ, Haehnel PS, Mustafa AM, Gurdal E, Schubert B, et al. Identification of a highly efficient dual type I/II FMS‐like tyrosine kinase inhibitor that disrupts the growth of leukemic cells. Cell Chem Biol. 2022;29(3):398–411.e4.
Fischer MA, Mustafa AM, Hausmann K, Ashry R, Kansy AG, Liebl MC, et al. Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells. J Adv Res. 2023;17(7):S2090‐1232.
Alfayomy AM, Ashry R, Kansy AG, Erdmann F, Schmidt M, Krämer OH, et al. Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the Ataxia telangiectasia and RAD3‐related (ATR) kinase. Eur J Med Chem. 2024;5(3):267.
Nguyen TM, Deb A, Praveen Kokkonda P, Vedagopuram Sreekanth V, Tiwari PK, Shoba V, et al. Proteolysis targeting chimeras with reduced off‐targets. Nat Chem. 2024;16(2):218–228.
Toledo L, Neelsen KJ, Lukas J. Replication catastrophe: when a checkpoint fails because of exhaustion. Mol Cell. 2017;66(6):735–749.
Rogakou EP, Nieves‐Neira W, Boon C, Pommier Y, Bonner WM. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem. 2000;275(13):9390–9395.

Auteurs

Anita G Kansy (AG)

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Ramy Ashry (R)

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Department of Oral Pathology, Faculty of Dentistry, Mansoura University, Egypt.

Al-Hassan M Mustafa (AM)

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Department of Zoology, Faculty of Science, Aswan University, Egypt.

Abdallah M Alfayomy (AM)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

Markus P Radsak (MP)

3rd Department Medicine, University Medical Center Mainz, Germany.

Yanira Zeyn (Y)

Department of Dermatology, University Medical Center Mainz, Germany.

Matthias Bros (M)

Department of Dermatology, University Medical Center Mainz, Germany.

Wolfgang Sippl (W)

Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany.

Oliver H Krämer (OH)

Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Classifications MeSH