Physical function patient-reported outcomes among adolescent and young adult cancer survivors: A systematic review.
adolescent
cancer
cancer survivors
patient‐reported outcome measures
physical function
routinely collected health data
young adult
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
19
01
2024
received:
27
10
2023
accepted:
13
02
2024
medline:
23
3
2024
pubmed:
23
3
2024
entrez:
23
3
2024
Statut:
ppublish
Résumé
The physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient-reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life. We compared patient-reported physical function outcomes between AYAs diagnosed with cancer and non-cancer controls. This paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function. This systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer-free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta-analysis conducted on 5 studies using the EORTC-QLQ-C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: -10.21, -3.86) points lower in the AYA cancer group, compared to their cancer free-peers, a difference that is clinically meaningful. The results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health-related quality of life from a physical function perspective than their cancer-free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross-sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey.
Sections du résumé
BACKGROUND
BACKGROUND
The physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient-reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life.
OBJECTIVE
OBJECTIVE
We compared patient-reported physical function outcomes between AYAs diagnosed with cancer and non-cancer controls.
METHOD
METHODS
This paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function.
RESULTS
RESULTS
This systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer-free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta-analysis conducted on 5 studies using the EORTC-QLQ-C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: -10.21, -3.86) points lower in the AYA cancer group, compared to their cancer free-peers, a difference that is clinically meaningful.
CONCLUSIONS
CONCLUSIONS
The results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health-related quality of life from a physical function perspective than their cancer-free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross-sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e7046Informations de copyright
© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Références
Janssen SHM, van der Graaf WTA, van der Meer DJ, Manten‐Horst E, Husson O. Adolescent and young adult (AYA) cancer survivorship practices: an overview. Cancers (Basel). 2021;13(19):4847.
Keegan TH, Ries LA, Barr RD, et al. Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. Cancer. 2016;122(7):1009‐1016.
Miller KD, Fidler‐Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL. Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin. 2020;70(6):443‐459.
Schulte FSM, Chalifour K, Eaton G, Garland SN. Quality of life among survivors of adolescent and young adult cancer in Canada: a young adults with cancer in their prime (YACPRIME) study. Cancer. 2021;127(8):1325‐1333.
Azam F, Latif MF, Farooq A, et al. Performance status assessment by using ECOG (eastern cooperative oncology group) score for cancer patients by oncology healthcare professionals. Case Rep Oncol. 2019;12(3):728‐736.
Larsen RF, Jarden M, Minet LR, Frølund UC, Möller S, Abildgaard N. Physical function in patients newly diagnosed with multiple myeloma; a Danish cohort study. BMC Cancer. 2020;20(1):169.
Pandya C, Magnuson A, Flannery M, et al. Association between symptom burden and physical function in older patients with cancer. J Am Geriatr Soc. 2019;67(5):998‐1004.
Grusdat NP, Stäuber A, Tolkmitt M, et al. Routine cancer treatments and their impact on physical function, symptoms of cancer‐related fatigue, anxiety, and depression. Support Care Cancer. 2022;30(5):3733‐3744.
Kirchhoff AC, Spraker‐Perlman HL, McFadden M, et al. Sociodemographic disparities in quality of life for survivors of adolescent and young adult cancers in the behavioral risk factor surveillance system. J Adolesc Young Adult Oncol. 2014;3(2):66‐74.
Weldring T, Smith SM. Patient‐reported outcomes (PROs) and patient‐reported outcome measures (PROMs). Health Serv Insights. 2013;6:61‐68.
Engstrom T, Tanner S, Lee WR, et al. Patient reported outcome measure domains and tools used among adolescents and young adults with cancer: a scoping review. Crit Rev Oncol/Hematol. 2022;181:103867.
Tanner S, Engstrom T, Lee WR, et al. Mental health patient‐reported outcomes among adolescents and young adult cancer survivors: a systematic review. Cancer Med. 2023;12(17):18381‐18393.
Sterne JA, Hernán MA, Reeves BC, et al. ROBINS‐I: a tool for assessing risk of bias in non‐randomised studies of interventions. BMJ. 2016;355:i4919.
Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of cancer QLQ‐C30: a quality‐of‐life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365‐376.
Balduzzi S, Rücker G, Schwarzer G. How to perform a meta‐analysis with R: a practical tutorial. Evid Based Ment Health. 2019;22(4):153‐160.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Hall AE, Boyes AW, Bowman J, Walsh RA, James EL, Girgis A. Young adult cancer survivors' psychosocial well‐being: a cross‐sectional study assessing quality of life, unmet needs, and health behaviors. Support Care Cancer. 2012;20(6):1333‐1341.
Schwartz LA, Parisi ML. Self‐identified goals of adolescents with cancer and healthy peers: content, appraisals, and correlates. J Pediatr Psychol. 2013;38(2):151‐161.
Bártolo A, Neves M, Carvalho B, et al. Fertility under uncertainty: exploring differences in fertility‐related concerns and psychosocial aspects between breast cancer survivors and non‐cancer infertile women. Breast Cancer. 2020;27(6):1177‐1186.
Bradford N, Walker R, Cashion C, Henney R, Yates P. Do specialist youth cancer services meet the physical, psychological and social needs of adolescents and young adults? A cross sectional study. Eur J Oncol Nurs. 2020;44:101709.
Drabbe C, Van der Graaf WTA, De Rooij BH, et al. The age‐related impact of surviving sarcoma on health‐related quality of life: data from the SURVSARC study. ESMO Open. 2021;6(1):100047.
Frøding LP, Ottosen C, Mosgaard BJ, Jensen PT. Quality of life, urogynecological morbidity, and lymphedema after radical vaginal trachelectomy for early‐stage cervical cancer. Int J Gynecol Cancer. 2015;25(4):699‐706.
Geue K, Sender A, Schmidt R, et al. Gender‐specific quality of life after cancer in young adulthood: a comparison with the general population. Qual Life Res. 2014;23(4):1377‐1386.
Harju E, Roser K, Dehler S, Michel G. Health‐related quality of life in adolescent and young adult cancer survivors. Support Care Cancer. 2018;26(9):3099‐3110.
Husson O, Zebrack BJ, Block R, et al. Health‐related quality of life in adolescent and young adult patients with cancer: a longitudinal study. J Clin Oncol. 2017;35(6):652‐659.
Salsman JM, Garcia SF, Yanez B, Sanford SD, Snyder MA, Victorson D. Physical, emotional, and social health differences between posttreatment young adults with cancer and matched healthy controls. Cancer. 2014;120(15):2247‐2254.
Seitz DC, Hagmann D, Besier T, et al. Life satisfaction in adult survivors of cancer during adolescence: what contributes to the latter satisfaction with life? Qual Life Res. 2011;20(2):225‐236.
Smith AW, Bellizzi KM, Keegan TH, et al. Health‐related quality of life of adolescent and young adult patients with cancer in the United States: the adolescent and young adult health outcomes and patient experience study. J Clin Oncol. 2013;31(17):2136‐2145.
Tai E, Buchanan N, Townsend J, Fairley T, Moore A, Richardson LC. Health status of adolescent and young adult cancer survivors. Cancer. 2012;118(19):4884‐4891.
Warner EL, Nam GE, Zhang Y, et al. Health behaviors, quality of life, and psychosocial health among survivors of adolescent and young adult cancers. J Cancer Surviv. 2016;10(2):280‐290.
Monteiro S, Torres A, Morgadinho R, Pereira A. Psychosocial outcomes in young adults with cancer: emotional distress, quality of life and personal growth. Arch Psychiatr Nurs. 2013;27(6):299‐305.
Mols F, Schoormans D, Smit JWA, et al. Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: results from the PROFILES registry. Head Neck. 2018;40(10):2235‐2245.
Musoro JZ, Coens C, Sprangers MAG, et al. Minimally important differences for interpreting EORTC QLQ‐C30 change scores over time: a synthesis across 21 clinical trials involving nine different cancer types. Eur J Cancer. 2023;188:171‐182.
Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health‐related quality‐of‐life scores. J Clin Oncol. 1998;16(1):139‐144.
Nekhlyudov L, Campbell GB, Schmitz KH, et al. Cancer‐related impairments and functional limitations among long‐term cancer survivors: gaps and opportunities for clinical practice. Cancer. 2022;128(2):222‐229.
Jayadevappa R, Cook R, Chhatre S. Minimal important difference to infer changes in health‐related quality of life‐a systematic review. J Clin Epidemiol. 2017;89:188‐198.
Busija L, Ackerman IN, Haas R, et al. Adult measures of general health and health‐related quality of life. Arthritis Care Res. 2020;72(S10):522‐564.
Mouelhi Y, Jouve E, Castelli C, Gentile S. How is the minimal clinically important difference established in health‐related quality of life instruments? Review of anchors and methods. Health Qual Life Outcomes. 2020;18(1):136.
Ness KK, Wall MM, Oakes JM, Robison LL, Gurney JG. Physical performance limitations and participation restrictions among cancer survivors: a population‐based study. Ann Epidemiol. 2006;16(3):197‐205.
Cespedes Feliciano EM, Vasan S, Luo J, et al. Long‐term trajectories of physical function decline in women with and without cancer. JAMA Oncol. 2023;9(3):395‐403.
Helseth E, Due‐Tønnessen B, Wesenberg F, Lote K, Lundar T. Posterior fossa medulloblastoma in children and young adults (0–19 years): survival and performance. Childs Nerv Syst. 1999;15(9):451‐455.
Hoffman MC, Mulrooney DA, Steinberger J, Lee J, Baker KS, Ness KK. Deficits in physical function among young childhood cancer survivors. J Clin Oncol. 2013;31(22):2799‐2805.
Renard AJ, Veth RP, Schreuder HWB, van Loon CJ, Koops HS, van Horn JR. Function and complications after ablative and limb‐salvage therapy in lower extremity sarcoma of bone. J Surg Oncol. 2000;73(4):198‐205.
Nakano J, Fukushima T, Tanaka T, Fu JB, Morishita S. Physical function predicts mortality in patients with cancer: a systematic review and meta‐analysis of observational studies. Support Care Cancer. 2021;29(10):5623‐5634.
Schink K, Gaßner H, Reljic D, et al. Assessment of gait parameters and physical function in patients with advanced cancer participating in a 12‐week exercise and nutrition programme: a controlled clinical trial. Eur J Cancer Care. 2020;29(2):e13199.
Lund CM, Dolin TG, Mikkelsen MK, Juhl CB, Vinther A, Nielsen DL. Effect of exercise on physical function and psychological well‐being in older patients with colorectal cancer receiving chemotherapy‐a systematic review. Clin Colorectal Cancer. 2020;19(4):e243‐e257.
Wayant C, Bixler K, Garrett M, Mack JW, Wright D, Vassar M. Evaluation of patient‐reported outcome measures of positive psychosocial constructs in children and adolescent/young adults with cancer: a systematic review of measurement properties. J Adolesc Young Adult Oncol. 2022;11(1):78‐94.
Rose MS, Koshman ML, Spreng S, Sheldon R. Statistical issues encountered in the comparison of health‐related quality of life in diseased patients to published general population norms: problems and solutions. J Clin Epidemiol. 1999;52(5):405‐412.