Early post-operative lactate increase following kidney transplant is associated with delayed graft function: A retrospective cohort study.
delayed‐graft function
kidney transplant
outcome
prognosis
venous lactate variation
Journal
Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
25
02
2024
received:
05
01
2024
accepted:
27
02
2024
medline:
23
3
2024
pubmed:
23
3
2024
entrez:
23
3
2024
Statut:
ppublish
Résumé
Delayed graft function (DGF) is a frequent complication following kidney transplant. This study aimed to assess the association between early post-operative lactate variation and DGF. This was a single center, retrospective cohort study between February 2021 and December 2022 in Saint-Louis Hospital (APHP, France). Venous lactate levels were measured immediately (H0) and 4 h (H4) after kidney transplant. The primary outcome was the occurrence of DGF (need for renal replacement therapy between transplantation and day 7). Secondary outcome was the occurrence of complications (i.e., death, vascular thrombosis, hemorrhagic shock, urological complications (hematoma, urinoma), local or systemic infection) between transplant and day 7. Two hundred 12 patients were included, and 38 (17.9%) developed DGF. Venous lactate variation between H0 and H4 was higher in patients who developed DGF (-30 (IQR -83, -6)% vs. -15 (IQR -62, -11)%, p = .037), but the variation of level was more often positive (corresponding to an increased lactate production over time between H0 and H4) in patients who developed DGF ((28(85%) vs. 94(62%), p = .011). In multivariate logistic regression, positive venous lactate level variation between H0 and H4 was strongly associated with a reduced risk of developing DGF (OR .30 [.09-.79], p = .024). We did not find any association between post-operative hyperlactatemia and occurrence of complications between transplant and day 7. DGF is a frequent complication following kidney transplantation. Its early prediction could help physicians optimize treatment and protect the kidney. Early venous lactate variation after kidney transplant could help to predict the occurrence of DGF.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15288Informations de copyright
© 2024 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd.
Références
Mannon RB. Delayed graft function: the AKI of kidney transplantation. Nephron. 2018;140(2):94‐98. doi:10.1159/000491558
Wu J, Zhang F, Zheng X, et al. Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap‐related genes. Front Immunol. 2022;13:1047367. doi:10.3389/fimmu.2022.1047367
Quaglia M, Merlotti G, Guglielmetti G, Castellano G, Cantaluppi V. Recent advances on biomarkers of early and late kidney graft dysfunction. Int J Mol Sci. 2020;21(15):5404. doi:10.3390/ijms21155404
Yadav B, Prasad N, Agrawal V, et al. Urinary kidney injury molecule‐1 can predict delayed graft function in living donor renal allograft recipients. Nephrology (Carlton). 2015;20(11):801‐806. doi:10.1111/nep.12511
Maier HT, Ashraf MI, Denecke C, et al. Prediction of delayed graft function and long‐term graft survival by serum and urinary neutrophil gelatinase‐associated lipocalin during the early postoperative phase after kidney transplantation. PLoS ONE. 2018;13(1):e0189932. doi:10.1371/journal.pone.0189932
Bakker J, Nijsten MW, Jansen TC. Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care. 2013;3(1):12. doi:10.1186/2110‐5820‐3‐12
Fuller BM, Dellinger RP. Lactate as a hemodynamic marker in the critically ill. Curr Opin Crit Care. 2012;18(3):267‐272. doi:10.1097/MCC.0b013e3283532b8a
Masyuk M, Wernly B, Lichtenauer M, et al. Prognostic relevance of serum lactate kinetics in critically ill patients. Intensive Care Med. 2019;45(1):55‐61. doi:10.1007/s00134‐018‐5475‐3
Hayashida K, Suzuki M, Yonemoto N, et al. Early lactate clearance is associated with improved outcomes in patients with postcardiac arrest syndrome: a prospective, multicenter observational study (SOS‐KANTO 2012 study). Crit Care Med. 2017;45(6):e559‐e566. doi:10.1097/CCM.0000000000002307
Odom SR, Howell MD, Silva GS, et al. Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg. 2013;74(4):999‐1004. doi:10.1097/TA.0b013e3182858a3e
Zhang Z, Xu X. Lactate clearance is a useful biomarker for the prediction of all‐cause mortality in critically ill patients: a systematic review and meta‐analysis*. Crit Care Med. 2014;42(9):2118‐2125. doi:10.1097/CCM.0000000000000405
von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007;147(8):573‐577. doi:10.7326/0003‐4819‐147‐8‐200710160‐00010
R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Published online 2020. https://www.R‐project.org/
Weil MH, Afifi AA. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation. 1970;41(6):989‐1001. doi:10.1161/01.cir.41.6.989
Andersen LW, Mackenhauer J, Roberts JC, Berg KM, Cocchi MN, Donnino MW. Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc. 2013;88(10):1127‐1140. doi:10.1016/j.mayocp.2013.06.012
Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11(11):2279‐2296. doi:10.1111/j.1600‐6143.2011.03754.x
Attaná P, Lazzeri C, Chiostri M, Picariello C, Gensini GF, Valente S. Lactate clearance in cardiogenic shock following ST elevation myocardial infarction: a pilot study. Acute Card Care. 2012;14(1):20‐26. doi:10.3109/17482941.2011.655293
Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med. 2004;32(8):1637‐1642. doi:10.1097/01.ccm.0000132904.35713.a7
Arnold RC, Shapiro NI, Jones AE, et al. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009;32(1):35‐39. doi:10.1097/shk.0b013e3181971d47
Zampieri FG, Damiani LP, Bakker J, et al. Effects of a resuscitation strategy targeting peripheral perfusion status versus serum lactate levels among patients with septic shock. A Bayesian reanalysis of the ANDROMEDA‐SHOCK trial. Am J Respir Crit Care Med. 2020;201(4):423‐429. doi:10.1164/rccm.201905‐0968OC
Hernández G, Ospina‐Tascón GA, Damiani LP, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28‐day mortality among patients with septic shock: the ANDROMEDA‐SHOCK randomized clinical trial. JAMA. 2019;321(7):654‐664. doi:10.1001/jama.2019.0071
Gu WJ, Zhang Z, Bakker J. Early lactate clearance‐guided therapy in patients with sepsis: a meta‐analysis with trial sequential analysis of randomized controlled trials. Intensive Care Med. 2015;41(10):1862‐1863. doi:10.1007/s00134‐015‐3955‐2
Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389(10075):1238‐1252. doi:10.1016/S0140‐6736(16)32064‐5
Lenain R, Prouteau C, Hamroun A, et al. Association between deceased donor acute kidney injury assessed using baseline serum creatinine back‐estimation and graft survival: results from the French national CRISTAL registry. Am J Kidney Dis. 2022;79(2):164‐174 doi:10.1053/j.ajkd.2021.06.022. Published online August 17, 2021:S0272‐6386(21)00770‐8.
Miller G, Ankerst DP, Kattan MW, et al. Kidney transplantation outcome predictions (KTOP): a risk prediction tool for kidney transplants from brain‐dead deceased donors based on a large European cohort. Eur Urol. 2023;83(2):173‐179. doi:10.1016/j.eururo.2021.12.008. Published online January 6, 2022:S0302‐2838(21)02216‐8.
Meier‐Kriesche HU, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant. 2004;4(3):378‐383. doi:10.1111/j.1600‐6143.2004.00332.x
Ergün M, Özdemir‐van Brunschot DMD, Donders RART, Hilbrands LB, Hoitsma AJ, Warlé MC. Prolonged duration of brain death was associated with better kidney allograft function and survival: a prospective cohort analysis. Ann Transplant. 2019;24:147‐154. doi:10.12659/AOT.913869
Seth A, Sharma A, Kenwar DB, et al. Risk for delayed graft function in deceased donor renal transplant patients: a single‐center experience from North India. Transplant Proc. 2020;52(6):1741‐1743. doi:10.1016/j.transproceed.2020.04.003
Ponticelli C, Reggiani F, Moroni G. Delayed graft function in kidney transplant: risk factors, consequences and prevention strategies. J Pers Med. 2022;12(10):1557. doi:10.3390/jpm12101557