Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients.
Cancer disparities
Oral and pharynx cancer
Race
Survival
Journal
Cancer causes & control : CCC
ISSN: 1573-7225
Titre abrégé: Cancer Causes Control
Pays: Netherlands
ID NLM: 9100846
Informations de publication
Date de publication:
23 Mar 2024
23 Mar 2024
Historique:
received:
27
10
2023
accepted:
20
02
2024
medline:
23
3
2024
pubmed:
23
3
2024
entrez:
23
3
2024
Statut:
aheadofprint
Résumé
Disparities in oral cavity and pharyngeal cancer based on race/ethnicity and socioeconomic status have been reported, but the impact of living within areas that are persistently poor at the time of diagnosis and outcome is unknown. This study aimed to investigate whether the incidence, 5-year relative survival, stage at diagnosis, and mortality among patients with oral cavity and pharyngeal cancers varied by persistent poverty. Data were drawn from the SEER database (2006-2017) and included individuals diagnosed with oral cavity and pharyngeal cancers. Persistent poverty (at census tract) is defined as areas where ≥ 20% of the population has lived below the poverty level for ~ 30 years. Age-adjusted incidence and 5-year survival rates were calculated. Multivariable logistic regression was used to estimate the association between persistent poverty and advanced stage cancer. Cumulative incidence and multivariable subdistribution hazard models were used to evaluate mortality risk. In addition, results were stratified by cancer primary site, sex, race/ethnicity, and rurality. Of the 90,631 patients included in the analysis (61.7% < 65 years old, 71.6% males), 8.8% lived in persistent poverty. Compared to non-persistent poverty, patients in persistent poverty had higher incidence and lower 5-year survival rates. Throughout 10 years, the cumulative incidence of cancer death was greater in patients from persistent poverty and were more likely to present with advanced-stage cancer and higher mortality risk. In the stratified analysis by primary site, patients in persistent poverty with oropharyngeal, oral cavity, and nasopharyngeal cancers had an increased risk of mortality compared to the patients in non-persistent poverty. This study found an association between oral cavity and pharyngeal cancer outcomes among patients in persistent poverty indicating a multidimensional strategy to improve survival.
Identifiants
pubmed: 38520565
doi: 10.1007/s10552-024-01867-3
pii: 10.1007/s10552-024-01867-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA: Cancer J Clinicians 73(1):17–48
Ward E, Jemal A, Cokkinides V, Singh GK, Cardinez C, Ghafoor A et al (2004) Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clinicians. 54(2):78–93
doi: 10.3322/canjclin.54.2.78
Auluck A, Walker BB, Hislop G, Lear SA, Schuurman N, Rosin M (2014) Population-based incidence trends of oropharyngeal and oral cavity cancers by sex among the poorest and underprivileged populations. BMC Cancer 14(1):316
doi: 10.1186/1471-2407-14-316
pubmed: 24886308
pmcid: 4022437
Karanth SD, Akinyemiju T, Walker CJ, Yang D, Migliorati CA, Yoon H-S et al (2023) The Intersectionality between race, ethnicity, and residential-level socioeconomic status in disparities of head and neck cancer outcomes: a SEER study. Cancer Epidemiol Biomark Prev 32(4):516–523
doi: 10.1158/1055-9965.EPI-22-1167
Miller KK, Crandall MS, Weber BA (2002) Persistent poverty and place: how do persistent poverty and poverty demographics vary across the rural-urban continuum. Measuring Rural Diversity 2002 [Google Scholar]
Moss JL, Pinto CN, Srinivasan S, Cronin KA, Croyle RT (2020) Persistent poverty and cancer mortality rates: an analysis of county-level poverty designations. Cancer Epidemiol Biomark Prev 29(10):1949–1954
doi: 10.1158/1055-9965.EPI-20-0007
Moss JL, Pinto CN, Srinivasan S, Cronin KA, Croyle RT (2022) Enduring cancer disparities by persistent poverty, rurality, and race: 1990–1992 to 2014–2018. J Natl Cancer Inst 114(6):829–836
doi: 10.1093/jnci/djac038
pubmed: 35238347
pmcid: 9194626
Beech BM, Ford C, Thorpe RJ Jr, Bruce MA, Norris KC (2021) Poverty, racism, and the public health crisis in America. Front Public Health 9:699049
doi: 10.3389/fpubh.2021.699049
pubmed: 34552904
pmcid: 8450438
Beale CL (1980) The ethnic dimension of persistent poverty in rural and small-town areas. Racial/Ethnic Minorities in Rural Areas: Progress and Stagnation 1980-90:26
Bennett KJ, Probst JC, Pumkam C (2011) Obesity among working age adults: the role of county-level persistent poverty in rural disparities. Health Place 17(5):1174–1181
doi: 10.1016/j.healthplace.2011.05.012
pubmed: 21665515
Blake KD, Moss JL, Gaysynsky A, Srinivasan S, Croyle RT (2017) Making the case for investment in rural cancer control: an analysis of rural cancer incidence, mortality, and funding trends. Cancer Epidemiol Biomarkers Prev 26(7):992–997
doi: 10.1158/1055-9965.EPI-17-0092
pubmed: 28600296
pmcid: 5500425
Crawford SM, Sauerzapf V, Haynes R, Zhao H, Forman D, Jones AP (2009) Social and geographical factors affecting access to treatment of lung cancer. Br J Cancer 101(6):897–901
doi: 10.1038/sj.bjc.6605257
pubmed: 19690543
pmcid: 2743361
Moss JL, Liu B, Feuer EJ (2017) Urban/rural differences in breast and cervical cancer incidence: the mediating roles of socioeconomic status and provider density. Womens Health Issues 27(6):683–691
doi: 10.1016/j.whi.2017.09.008
pubmed: 29108988
pmcid: 5694385
Bennett KJ, Pumkam C, Bellinger JD, Probst JC (2011) Cancer screening delivery in persistent poverty rural counties. J Prim Care Community Health 2(4):240–249
doi: 10.1177/2150131911406123
pubmed: 23804842
Surveillance, Epidemiology, and End Results (SEER) Program. (2020) SEER*Stat Database: Incidence—SEER Research Data, 18 Registries (2000–2018), National Cancer Institute, DCCPS, Surveillance Research Program, released April 2021, based on the November 2020 submission. www.seer.cancer.gov
World Health Organization (2013) International classification of diseases for oncology (ICD-O). World Health Organization
USDA: poverty area measures. https://www.ers.usda.gov/data-products/poverty-area-measures/
Definition of all-cause mortality—NCI Dictionary of Cancer Terms—NCI (2011). https://www.cancer.gov/publications/dictionaries/cancer-terms/def/all-cause-mortality
Definition of cause-specific survival—NCI Dictionary of Cancer Terms—NCI (2011). https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cause-specific-survival
Surveillance, Epidemiology, and End Results Program. SEER https://seer.cancer.gov/index.html
US Department of Agriculture. Rural-urban continuum codes: overview. Published 2013. http://www.ers.usda.gov/data-products/rural-urban-continuum-codes.aspx
Tiwari RC, Clegg LX, Zou Z (2006) Efficient interval estimation for age-adjusted cancer rates. Stat Methods Med Res 15(6):547–569
doi: 10.1177/0962280206070621
pubmed: 17260923
Zhang MJ, Zhang X, Scheike TH (2008) Modeling cumulative incidence function for competing risks data. Expert Rev Clin Pharmacol 1(3):391–400
doi: 10.1586/17512433.1.3.391
pubmed: 19829754
pmcid: 2760993
Schoenfeld D (1982) Partial residuals for the proportional hazards regression model. Biometrika 69(1):239–241
doi: 10.1093/biomet/69.1.239
Holm S. A simple sequentially rejective multiple test procedure. Scandinavian journal of statistics. 1979:65–70.
341 U.S. Counties experiencing persistent poverty. https://www.census.gov/library/stories/2023/05/persistent-poverty-areas-with-long-term-high-poverty.html
Weng Y, Korte JE (2012) Racial disparities in being recommended to surgery for oral and oropharyngeal cancer in the United States. Comm Dent Oral Epidemiol 40(1):80–88
doi: 10.1111/j.1600-0528.2011.00638.x
Megwalu UC (2017) Impact of county-level socioeconomic status on oropharyngeal cancer survival in the United States. Otolaryngol Head Neck Surg 156(4):665–670
doi: 10.1177/0194599817691462
pubmed: 28195022
Panth N, Simpson MC, Sethi RKV, Varvares MA, Osazuwa-Peters N (2020) Insurance status, stage of presentation, and survival among female patients with head and neck cancer. Laryngoscope 130(2):385–391
doi: 10.1002/lary.27929
pubmed: 30900256
Emerson MA, Farquhar DR, Lenze NR, Sheth S, Mazul AL, Zanation AM et al (2022) Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. Head Neck 44(4):823–834
doi: 10.1002/hed.26977
pubmed: 35044015
pmcid: 8904304
Massa ST, Liebendorfer AP, Zevallos JP, Mazul AL (2020) Distance traveled to head and neck cancer provider: a measure of socioeconomic status and access. Otolaryngol Head Neck Surg 162(2):193–203
doi: 10.1177/0194599819892015
pubmed: 31794337
David JM, Ho AS, Luu M, Yoshida EJ, Kim S, Mita AC et al (2017) Treatment at high-volume facilities and academic centers is independently associated with improved survival in patients with locally advanced head and neck cancer. Cancer 123(20):3933–3942
doi: 10.1002/cncr.30843
pubmed: 28640546
Brisson M, Drolet M, Malagón T (2013) Inequalities in human papillomavirus (HPV)–associated cancers: implications for the success of HPV vaccination. J Natl Cancer Inst 105(3):158–161
doi: 10.1093/jnci/djs638
pubmed: 23297040
Kravietz A, Angara P, Le M, Sargi Z (2018) Disparities in screening for head and neck cancer: evidence from the NHANES, 2011–2014. Otolaryngol-Head Neck Surg 159(4):683–691
doi: 10.1177/0194599818773074
pubmed: 29712503
Vengaloor Thomas T, Krishna K, Ahmed HZ, Mundra E, Abraham A, Bhanat E et al (2020) A 25-year experience at an academic medical center in the United States: are there racial disparities in the prognosis of patients diagnosed with hypopharyngeal carcinoma? Cureus 12(11):e11306
pubmed: 33282583
pmcid: 7714743
Vengaloor Thomas T, Nittala MR, Bhanat E, Albert AA, Vijayakumar S (2020) Management of advanced-stage hypopharyngeal carcinoma: 25-year experience from a tertiary care medical center. Cureus 12(1):e6679
pubmed: 32104619
pmcid: 7026862
Adler NE, Newman K (2002) Socioeconomic disparities in health: pathways and policies. Health Aff 21(2):60–76
doi: 10.1377/hlthaff.21.2.60
Taylor SE, Repetti RL, Seeman T (1997) Health psychology: what is an unhealthy environment and how does it get under the skin? Annu Rev Psychol 48:411–447
doi: 10.1146/annurev.psych.48.1.411
pubmed: 9046565
Almeida DM, Neupert SD, Banks SR, Serido J (2005) Do daily stress processes account for socioeconomic health disparities? J Gerontol: Ser B. 60:S34–S39
doi: 10.1093/geronb/60.Special_Issue_2.S34