Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action.
Apoptosis
Cancer
Cytotoxicity
Heterocycle
Mitochondria
Pharmacology
Phthalate
Phthalimide
Pyrone
Triterpene
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
18 Mar 2024
18 Mar 2024
Historique:
received:
01
03
2024
revised:
13
03
2024
accepted:
14
03
2024
medline:
24
3
2024
pubmed:
24
3
2024
entrez:
23
3
2024
Statut:
aheadofprint
Résumé
A series of triterpenoid pyrones was synthesized and subsequently modified to introduce phthalimide or phthalate moieties into the triterpenoid skeleton. These compounds underwent in vitro cytotoxicity screening, revealing that a subset of six compounds exhibited potent activity, with IC
Identifiants
pubmed: 38520761
pii: S0223-5234(24)00216-2
doi: 10.1016/j.ejmech.2024.116336
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116336Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.