Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID.
Adolescents
Children
ISGs
Long COVID
Neutralizing autoantibodies to interferon
SARS‐CoV‐2
Type I interferon
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
24 Mar 2024
24 Mar 2024
Historique:
revised:
26
02
2024
received:
25
07
2023
accepted:
26
02
2024
medline:
24
3
2024
pubmed:
24
3
2024
entrez:
24
3
2024
Statut:
aheadofprint
Résumé
SARS-CoV-2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon (IFN-I) response in children and adolescents with LC symptoms (LC; n = 28). This was compared with age-matched SARS-CoV-2 recovered participants without LC symptoms (MC; n = 28) and healthy controls (HC; n = 18). We measured the mRNA expression of IFN-I (IFN-α/β/ε/ω), IFN-I receptor (IFNAR1/2), and ISGs (ISG15, ISG56, MxA, IFI27, BST2, LY6E, OAS1, OAS2, OAS3, and MDA5) in PBMCs collected 3-6 months after COVID-19. LC adolescents (12-17 years) had higher transcript levels of IFN-β, IFN-ε, and IFN-ω than HC, whereas LC children (6-11 years) had lower levels than HC. In adolescents, increased levels of IFN-α, IFN-β, and IFN-ω mRNAs were found in the LC group compared with MC, while lower levels were observed in LC children than MC. Adolescents with neurological symptoms had higher IFN-α/β mRNA levels than MC. LC and MC participants showed decreased expression of ISGs and IFNAR1, but increased expression of IFNAR2, than HC. Our results show age-related changes in the expression of transcripts involved in the IFN-I signaling pathway in children and adolescents with LC.
Identifiants
pubmed: 38522030
doi: 10.1002/eji.202350682
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2350682Subventions
Organisme : EU
Organisme : NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases
ID : PE00000007
Organisme : Sapienza University of Rome
Organisme : Progetti Ricerca-Progetti Medi
ID : RM1221814ED155C3
Informations de copyright
© 2024 Wiley‐VCH GmbH.
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