Prevalence and causes of chronic cough in Japan.

Atopic cough Chronic cough Cough variant asthma Refractory chronic cough Unexplained chronic cough

Journal

Respiratory investigation
ISSN: 2212-5353
Titre abrégé: Respir Investig
Pays: Netherlands
ID NLM: 101581124

Informations de publication

Date de publication:
22 Mar 2024
Historique:
received: 29 11 2023
revised: 25 01 2024
accepted: 28 02 2024
medline: 25 3 2024
pubmed: 25 3 2024
entrez: 24 3 2024
Statut: aheadofprint

Résumé

Chronic cough is one of the most common symptoms of respiratory diseases and can adversely affect patients' quality of life and interfere with social activities, resulting in a significant social burden. A survey is required to elucidate the frequency and treatment effect of chronic cough. However, clinical studies that cover all of Japan have not yet been conducted. Patients who presented with a cough that lasted longer than 8 weeks and visited the respiratory clinics or hospitals affiliated with the Japan Cough Society during the 2-year study period were registered. A total of 379 patients were enrolled, and those who did not meet the definition of chronic cough were excluded. A total of 334 patients were analyzed: 201 patients had a single cause, and 113 patients had two or more causes. The main causative diseases were cough variant asthma in 92 patients, sinobronchial syndrome (SBS) in 36 patients, atopic cough in 31 patients, and gastroesophageal reflux (GER)-associated cough in 10 patients. The time required to treat undiagnosed patients and those with SBS was significantly longer and the treatment success rate for GER-associated cough was considerably poor. We confirmed that the main causes of chronic cough were cough variant asthma, SBS, atopic cough, and their complications. We also showed that complicated GER-associated cough was more likely to become refractory. This is the first nationwide study in Japan of the causes and treatment effects of chronic cough.

Sections du résumé

BACKGROUND BACKGROUND
Chronic cough is one of the most common symptoms of respiratory diseases and can adversely affect patients' quality of life and interfere with social activities, resulting in a significant social burden. A survey is required to elucidate the frequency and treatment effect of chronic cough. However, clinical studies that cover all of Japan have not yet been conducted.
METHODS METHODS
Patients who presented with a cough that lasted longer than 8 weeks and visited the respiratory clinics or hospitals affiliated with the Japan Cough Society during the 2-year study period were registered.
RESULTS RESULTS
A total of 379 patients were enrolled, and those who did not meet the definition of chronic cough were excluded. A total of 334 patients were analyzed: 201 patients had a single cause, and 113 patients had two or more causes. The main causative diseases were cough variant asthma in 92 patients, sinobronchial syndrome (SBS) in 36 patients, atopic cough in 31 patients, and gastroesophageal reflux (GER)-associated cough in 10 patients. The time required to treat undiagnosed patients and those with SBS was significantly longer and the treatment success rate for GER-associated cough was considerably poor.
CONCLUSIONS CONCLUSIONS
We confirmed that the main causes of chronic cough were cough variant asthma, SBS, atopic cough, and their complications. We also showed that complicated GER-associated cough was more likely to become refractory. This is the first nationwide study in Japan of the causes and treatment effects of chronic cough.

Identifiants

DOI: 10.1016/j.resinv.2024.02.017 PMID: 38522360
pubmed: 38522360
pii: S2212-5345(24)00042-X
doi: 10.1016/j.resinv.2024.02.017
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

442-448

Informations de copyright

Copyright © 2024 The Author. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest JH received honoraria from AstraZeneca Pharmaceuticals, United Kingdom; GlaxoSmithKline Pharmaceuticals, United Kingdom. SH received honoraria from AstraZeneca Pharmaceuticals, GlaxoSmithKline Pharmaceuticals, Kyorin Pharmaceuticals, Japan; Novartis Pharmaceuticals, Switzerland. NO received honoraria from AstraZeneca Pharmaceuticals and research funding from Konica Minolta K.K, Japan. HT received honoraria from AstraZeneca Pharmaceuticals, GlaxoSmithKline Pharmaceuticals, Kyorin Pharmaceuticals, Novartis Pharmaceuticals. TY received honoraria from Mitsubishi Tanabe Pharmaceuticals, Japan; Sanofi Pharmaceuticals, France; Kyorin Pharmaceuticals. TN received honoraria from AstraZeneca Pharmaceuticals, GlaxoSmithKline Pharmaceuticals, Kyorin Pharmaceuticals, Novartis Pharmaceuticals, Sanofi Pharmaceuticals. HiSag received honoraria from AstraZeneca Pharmaceuticals, GlaxoSmithKline Pharmaceuticals, Kracie Pharmaceuticals, Japan; Kyorin Pharmaceuticals, Novartis Pharmaceuticals, Sanofi Pharmaceuticals. HM received honoraria from Kyorin Pharmaceuticals. AN received honoraria from AstraZeneca Pharmaceuticals, GlaxoSmithKline Pharmaceuticals, Kyorin Pharmaceuticals, Novartis Pharmaceuticals, Sanofi Pharmaceuticals. The rest of the authors have no conflicts of interest.

Auteurs

Yoshihisa Ishiura (Y)

First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan. Electronic address: ishiuray@takii.kmu.ac.jp.

Masaki Fujimura (M)

Department of Respiratory Medicine, National Hospital Organization Nanao Hospital, 8 bu 3-1 Matsuto-machi, Nanao, 926-0841, Ishikawa, Japan; Cough Clinic, Komatsu Sophia Hospital, 478 Okimachi, Komatsu, Ishikawa, 923-0861, Japan.

Haruhiko Ogawa (H)

Department of Respiratory Medicine, Kanazawa Kasuga Clinic, Motogiku-machi, Kanazawa, Ishikawa, 920-0036, Japan.

Johsuke Hara (J)

Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Hiromoto Shintani (H)

Department of Respiratory Medicine, Shintani Medical Clinic, 67-1, Ni, Sono-machi, Komatsu, Ishikawa, 923-0801, Japan.

Soichiro Hozawa (S)

Department of Respiratory Medicine, Hiroshima Allergy and Respiratory Clinic, 1-9-28 Hikari-machi Higashi-ku, Hiroshima, 732-0052, Japan.

Ryo Atsuta (R)

Department of Respiratory Medicine, Akihabara Atsuta Clinic, 1-5 Kanada-Iwamotocho, 101-0033, Chiyoda, Tokyo, 101-0033, Japan.

Kensuke Fukumitsu (K)

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.

Hideki Inoue (H)

Department of Respiratory Medicine, Asthma and Lung Clinic Tokyo, 5-48-2 Higashi-Nippori, Arakawa-ku, Tokyo, 116-0014, Japan.

Takanobu Shioya (T)

Department of Respiratory Medicine, Nursing Care Facility Nikoniko-en, 138-1 Shimoshinjou Nakano Azabiwanuma, Akita, 010-0146, Japan.

Masato Muraki (M)

Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.

Tokunao Amemiya (T)

Department of Respiratory Medicine, Amemiya Clinic, 17-28 Yoshida-machi, Numazu, Shizuoka, 410-0836, Japan.

Noriyuki Ohkura (N)

Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Yoshitaka Oribe (Y)

Department of Respiratory Medicine, Oribe Internal Medicin Clinic, 1-5-33, Hikoso-machi, Kanazawa, Ishikawa, 920-0901, Japan.

Hiroshi Tanaka (H)

Department of Respiratory Medicine, NPO Sapporo Cough Asthma and Allergy Center, 15-1-32 Minami-4-jyou-Nishi, Sapporo, Hokkaido, 064-0804, Japan.

Takechiyo Yamada (T)

Department of Otorhinolaryngology, Head and Neck Surgery, Akita University, Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Mikio Toyoshima (M)

Department of Respiratory Medicine, Hamamatsu Rosai Hospital, 25 Shogen-cho, Cyuou-ku, Hamamatsu, Shizuoka, 430-8525, Japan.

Katsuya Fujimori (K)

Department of Internal Medicine, Agano City Hospital, 13-23 Okayamacho, Agano, Niigata, 959-2025, Japan.

Tamotsu Ishizuka (T)

Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan.

Manabu Kagaya (M)

KAGAYA CLINIC of Internal Medicine, 13-18 Asahikawa minami-machi, Akita, Akita, 010-0834, Japan.

Takeshi Suzuki (T)

Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8677, Japan.

Toshiyuki Kita (T)

Department of Respiratory Medicine, NHO Kanazawa Medical Center, 1-1 Shimoishibiki-machi, Kanazawa, Ishikawa 920-8650, Japan.

Koichi Nishi (K)

Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, 2-1 Kuratsuki-Higashi, Kanazawa, Ishikawa, 920-8530, Japan.

Akihito Ueda (A)

Department of Respiratory Medicine, Medical Corporation Toujinkai, Fujitate Hospital, 5-4-24 Ohmiya, Asahi-ku, Osaka, 535-0002, Japan.

Yoshito Miyata (Y)

Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.

Junya Kitada (J)

Ohmichi Clinic of Internal and Respiratory Medicine, Nihonseimei Sapporo Bldg, Kita-3, Nishi-4, Chuo-ku, Sapporo, (Hokkaido), 060-0003, Japan.

Kenta Yamamura (K)

Department of Internal Medicine, Keiju Medical Center, 94 Tomioka-cho, Nanao, Ishikawa, 926-8605, Japan.

Miki Abo (M)

Department of Respiratory Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Norihisa Takeda (N)

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.

Toshihiro Shirai (T)

Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, 4-27-1 Kita-Ando, Aoi-ku, Shizuoka, 420-8527, Japan.

Tomoko Tajiri (T)

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.

Shigemi Yoshihara (S)

Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuka-gun, Tochigi, 321-0293, Japan.

Taisuke Akamatsu (T)

Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, 4-27-1 Kita-Ando, Aoi-ku, Shizuoka, 420-8527, Japan.

Hirochiyo Sawaguchi (H)

Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.

Tatsuya Nagano (T)

Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Soichiro Hanada (S)

Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.

Sawako Masuda (S)

Department of Otorhinolaryngology, National Hospital Organization Mie National Hospital, 357 Osato-Kubota, Tsu, Mie, 514-0125, Japan.

Mitsuhide Ohmichi (M)

Ohmichi Clinic of Internal and Respiratory Medicine, Nihonseimei Sapporo Bldg, Kita-3, Nishi-4, Chuo-ku, Sapporo, (Hokkaido), 060-0003, Japan.

Tomoki Ito (T)

First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan.

Hironori Sagara (H)

Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.

Hisako Matsumoto (H)

Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama, Osaka, 589-8511, Japan.

Akio Niimi (A)

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawazumi Mizuho-machi, Nagoya, 467-860, Japan.

Classifications MeSH