Infra-inguinal Bypass Surgery versus Endovascular Revascularization for Chronic Limb-Threatening Ischemia in Average and High risk Patients.

This study aimed to evaluate treatment outcomes after bypass surgery or endovascular therapy (EVT) in average- and high-risk patients with chronic limb-threatening ischemia (CLTI). We retrospectively analyzed multicenter data of patients who underwent infra-inguinal revascularization for CLTI between 2015 and 2022. A high-risk patient was defined as one with estimated 30-day mortality rate ≥ 5% or 2-year survival rate ≤ 50%, as determined by the Surgical Reconstruction Versus Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH) calculator. The amputation-free survival (AFS), limb salvage (LS), wound healing, and 30-day mortality were compared separately for the average- and high-risk patients between the bypass and EVT with propensity score matching. We analyzed 239 and 31 propensity score matched pairs in the average- and high-risk patients with CLTI. In the average-risk patients, the 2-year AFS and LS rates were 78.1% and 94.4% in the bypass group and 63.0% and 87.7% in the EVT group (p < .001 and p = .007). The 1-year wound healing rates were 88.6% in the bypass group and 76.8% in the EVT group, respectively (p < .001). The 30-day mortality was 0.8% in the bypass surgery and 0.8% in the EVT group (p = .996). In the high-risk patients, there was no differences in the AFS, LS, and wound healing between the groups (p = .591, p = .148, and p = .074). The 30-day mortality was 3.2% in the bypass group and 3.2% in the EVT group (p = .991). Bypass surgery is superior to EVT with respect to the AFS, LS, and wound healing in the average-risk patients. EVT is a feasible first-line treatment strategy for high-risk patients with CLTI undergoing revascularization, based on the lack of significant differences in the 2-year AFS rate, between the bypass surgery and EVT cohorts.

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