Sex differences in response inhibition-related neural predictors of PTSD in recent trauma-exposed civilians.

Posttraumatic stress disorder (PTSD) functional Magnetic Resonance Imaging (fMRI) response inhibition right inferior frontal gyrus (rIFG) sex differences ventromedial prefrontal cortex (vmPFC)

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285

Informations de publication

Date de publication:
22 Mar 2024
Historique:
received: 29 11 2023
revised: 05 03 2024
accepted: 07 03 2024
medline: 25 3 2024
pubmed: 25 3 2024
entrez: 24 3 2024
Statut: aheadofprint

Résumé

Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as mechanism for PTSD development, but studies on the potential sex differences of this neurobiological mechanism and how it relates to PTSD severity and progression are sparse. Here we examined sex differences in neural activation during response inhibition and PTSD following recent trauma. Participants (N= 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event. PTSD symptoms were assessed 2-weeks and 6-months post-trauma. A Go/NoGo task was performed 2-weeks post-trauma in a 3T MRI scanner to measure neural activity during response inhibition in the ventromedial prefrontal cortex (vmPFC), right inferior frontal gyrus (rIFG), and the bilateral hippocampus. General Linear models were used to examine the interaction effect of sex on the relationship between our regions of interest (ROIs) and the whole brain, and PTSD symptoms at 6-months, and symptom progression between 2-weeks and 6-months. Lower response-inhibition-related vmPFC activation 2-weeks post-trauma predicted more PTSD symptoms at 6-months in females but not in males, while greater response-inhibition-related rIFG activation predicted lower PTSD symptom progression in males but not females. Whole brain interaction effects were observed in the medial temporal gyrus and left precentral gyrus. There are sex differences in the relationship between inhibition-related brain activation and PTSD symptom severity and progression. These findings suggest that sex differences should be assessed in future PTSD studies and reveal potential targets for sex-specific interventions.

Sections du résumé

BACKGROUND BACKGROUND
Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as mechanism for PTSD development, but studies on the potential sex differences of this neurobiological mechanism and how it relates to PTSD severity and progression are sparse. Here we examined sex differences in neural activation during response inhibition and PTSD following recent trauma.
METHODS METHODS
Participants (N= 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event. PTSD symptoms were assessed 2-weeks and 6-months post-trauma. A Go/NoGo task was performed 2-weeks post-trauma in a 3T MRI scanner to measure neural activity during response inhibition in the ventromedial prefrontal cortex (vmPFC), right inferior frontal gyrus (rIFG), and the bilateral hippocampus. General Linear models were used to examine the interaction effect of sex on the relationship between our regions of interest (ROIs) and the whole brain, and PTSD symptoms at 6-months, and symptom progression between 2-weeks and 6-months.
RESULTS RESULTS
Lower response-inhibition-related vmPFC activation 2-weeks post-trauma predicted more PTSD symptoms at 6-months in females but not in males, while greater response-inhibition-related rIFG activation predicted lower PTSD symptom progression in males but not females. Whole brain interaction effects were observed in the medial temporal gyrus and left precentral gyrus.
CONCLUSIONS CONCLUSIONS
There are sex differences in the relationship between inhibition-related brain activation and PTSD symptom severity and progression. These findings suggest that sex differences should be assessed in future PTSD studies and reveal potential targets for sex-specific interventions.

Identifiants

DOI: 10.1016/j.bpsc.2024.03.002 PMID: 38522649
pubmed: 38522649
pii: S2451-9022(24)00080-6
doi: 10.1016/j.bpsc.2024.03.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Bibian Borst (B)

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Tanja Jovanovic (T)

Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.

Stacey L House (SL)

Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Steven E Bruce (SE)

Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA.

Nathaniel G Harnett (NG)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Alyssa R Roeckner (AR)

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

Timothy D Ely (TD)

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

Lauren A M Lebois (LAM)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.

Dmitri Young (D)

University of California San Francisco, San Francisco, CA, USA.

Francesca L Beaudoin (FL)

Department of Epidemiology, Brown University, Providence, RI, USA; Department of Emergency Medicine, Brown University, Providence, RI.

Xinming An (X)

Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thomas C Neylan (TC)

Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA.

Gari D Clifford (GD)

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

Sarah D Linnstaedt (SD)

Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Laura T Germine (LT)

Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; The Many Brains Project, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Kenneth A Bollen (KA)

Department of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Scott L Rauch (SL)

Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

John P Haran (JP)

Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Alan B Storrow (AB)

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Christopher Lewandowski (C)

Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA.

Paul I Musey (PI)

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Phyllis L Hendry (PL)

Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.

Sophia Sheikh (S)

Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.

Christopher W Jones (CW)

Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA.

Brittany E Punches (BE)

Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, USA; Ohio State University College of Nursing, Columbus, OH, USA.

Lauren A Hudak (LA)

Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Jose L Pascual (JL)

Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Mark J Seamon (MJ)

Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Elizabeth M Datner (EM)

Department of Emergency Medicine, Jefferson Einstein hospital, Jefferson Health, Philadelphia, PA, USA; Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Claire Pearson (C)

Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, USA.

David A Peak (DA)

Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

Robert M Domeier (RM)

Department of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, USA.

Niels K Rathlev (NK)

Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.

Brian J O'Neil (BJ)

Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, USA.

Paulina Sergot (P)

Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, USA.

Leon D Sanchez (LD)

Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA.

Steven E Harte (SE)

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, USA.

Karestan C Koenen (KC)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Ronald C Kessler (RC)

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.

Samuel A McLean (SA)

Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Institute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Kerry J Ressler (KJ)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Jennifer S Stevens (JS)

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

Sanne J H van Rooij (SJH)

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: sanne.van.rooij@emory.edu.

Classifications MeSH