Infectious complications of transrectal prostate biopsy in patients receiving targeted antibiotic prophylaxis after urethral and rectal swab versus standard prophylaxis: A prospective comparative study.
Anti-bacterial agents
Biopsy
Prostate
Urinary tract infections
Journal
Prostate international
ISSN: 2287-8882
Titre abrégé: Prostate Int
Pays: Korea (South)
ID NLM: 101605566
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
25
10
2023
revised:
15
11
2023
accepted:
20
11
2023
medline:
25
3
2024
pubmed:
25
3
2024
entrez:
25
3
2024
Statut:
ppublish
Résumé
To evaluate the role of targeted antibiotic prophylaxis (TAP) after rectal and urethral swab cultures compared to empiric antibiotic prophylaxis (EAP) for the prevention of infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS-Bx). We conducted a prospective comparative study on 141 patients who underwent TRUS-Bx and were allocated in two groups. The first group (n = 71) received EAP with ciprofloxacin and the second (n = 70) received TAP according to rectal and urethral cultures. Post-biopsy infectious complications rates were compared between the two groups. Fluoroquinolone resistance (FQ-R) in the urethral and rectal swabs was recorded. Baseline characteristics were analyzed to assess their relationship with infectious complications and antibiotic resistance. A total of 8 infectious complications were observed, 7 of them in the EAP group (9.85%) and 1 in the TAP group (1.4%). There was a statistically significant difference in febrile UTIs between the two groups (6 vs 0, Combination of rectal and urethral swab cultures for TAP was able to detect FQ-R bacteria carriers and was associated with fewer infectious complications compared to EAP.
Sections du résumé
Background
UNASSIGNED
To evaluate the role of targeted antibiotic prophylaxis (TAP) after rectal and urethral swab cultures compared to empiric antibiotic prophylaxis (EAP) for the prevention of infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS-Bx).
Methods
UNASSIGNED
We conducted a prospective comparative study on 141 patients who underwent TRUS-Bx and were allocated in two groups. The first group (n = 71) received EAP with ciprofloxacin and the second (n = 70) received TAP according to rectal and urethral cultures. Post-biopsy infectious complications rates were compared between the two groups. Fluoroquinolone resistance (FQ-R) in the urethral and rectal swabs was recorded. Baseline characteristics were analyzed to assess their relationship with infectious complications and antibiotic resistance.
Results
UNASSIGNED
A total of 8 infectious complications were observed, 7 of them in the EAP group (9.85%) and 1 in the TAP group (1.4%). There was a statistically significant difference in febrile UTIs between the two groups (6 vs 0,
Conclusion
UNASSIGNED
Combination of rectal and urethral swab cultures for TAP was able to detect FQ-R bacteria carriers and was associated with fewer infectious complications compared to EAP.
Identifiants
pubmed: 38523904
doi: 10.1016/j.prnil.2023.11.002
pii: S2287-8882(23)00059-4
pmc: PMC10960084
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35-39Informations de copyright
© 2024 The Asian Pacific Prostate Society. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.