Metabolic Syndrome and Heart Transplantation: An Underestimated Risk Factor?

cardiac allograft vasculopathy heart transplantation long-term mortality long-term outcome metabolic syndrome

Journal

Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516

Informations de publication

Date de publication:
2024
Historique:
received: 24 11 2022
accepted: 02 01 2024
medline: 25 3 2024
pubmed: 25 3 2024
entrez: 25 3 2024
Statut: epublish

Résumé

Metabolic Syndrome (MetS), a multifactorial condition that increases the risk of cardio-vascular events, is frequent in Heart-transplant (HTx) candidates and worsens with immunosuppressive therapy. The aim of the study was to analyze the impact of MetS on long-term outcome of HTx patients. Since 2007, 349 HTx patients were enrolled. MetS was diagnosed if patients met revised NCEP-ATP III criteria before HTx, at 1, 5 and 10 years of follow-up. MetS was present in 35% of patients pre-HTx and 47% at 1 year follow-up. Five-year survival in patients with both pre-HTx (65% vs. 78%,

Identifiants

pubmed: 38525207
doi: 10.3389/ti.2024.11075
pii: 11075
pmc: PMC10959251
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11075

Informations de copyright

Copyright © 2024 Sponga, Vendramin, Ferrara, Marinoni, Valdi, Di Nora, Nalli, Benedetti, Piani, Lechiancole, Parpinel, Bortolotti and Livi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Sandro Sponga (S)

Department of Medicine (DAME), University of Udine, Udine, Italy.
Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Igor Vendramin (I)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Veronica Ferrara (V)

Department of Medicine (DAME), University of Udine, Udine, Italy.

Michela Marinoni (M)

Department of Medicine (DAME), University of Udine, Udine, Italy.

Giulia Valdi (G)

Department of Medicine (DAME), University of Udine, Udine, Italy.

Concetta Di Nora (C)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Chiara Nalli (C)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Giovanni Benedetti (G)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Daniela Piani (D)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Andrea Lechiancole (A)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Maria Parpinel (M)

Department of Medicine (DAME), University of Udine, Udine, Italy.

Uberto Bortolotti (U)

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Ugolino Livi (U)

Department of Medicine (DAME), University of Udine, Udine, Italy.
Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Classifications MeSH