The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats.
Glucose solution
methotrexate
renal injury
saline solution
Journal
Advanced biomedical research
ISSN: 2277-9175
Titre abrégé: Adv Biomed Res
Pays: India
ID NLM: 101586897
Informations de publication
Date de publication:
2024
2024
Historique:
received:
10
08
2022
revised:
25
01
2023
accepted:
01
02
2023
medline:
25
3
2024
pubmed:
25
3
2024
entrez:
25
3
2024
Statut:
epublish
Résumé
High-dose methotrexate (HDMTX) as a cytotoxic agent might cause various side effects. Hyperhydration has been implemented as the major strategy to decrease the potential risk of toxicities induced by HDMTX. This study aims to assess the renoprotective effect of hydration with dextrose water (DW) 5% versus normal saline (N/S) 0.9% against methotrexate (MTX) induced nephrotoxicity. This experimental animal study has been conducted on 36 Wistar rats (200-250 g) categorized into six groups, including male ( The groups were not significantly different with regard to blood urea nitrogen (BUN) ( Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.
Sections du résumé
Background
UNASSIGNED
High-dose methotrexate (HDMTX) as a cytotoxic agent might cause various side effects. Hyperhydration has been implemented as the major strategy to decrease the potential risk of toxicities induced by HDMTX. This study aims to assess the renoprotective effect of hydration with dextrose water (DW) 5% versus normal saline (N/S) 0.9% against methotrexate (MTX) induced nephrotoxicity.
Materials and Methods
UNASSIGNED
This experimental animal study has been conducted on 36 Wistar rats (200-250 g) categorized into six groups, including male (
Results
UNASSIGNED
The groups were not significantly different with regard to blood urea nitrogen (BUN) (
Conclusion
UNASSIGNED
Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.
Identifiants
pubmed: 38525397
doi: 10.4103/abr.abr_269_22
pii: ABR-13-14
pmc: PMC10958733
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Informations de copyright
Copyright: © 2024 Advanced Biomedical Research.
Déclaration de conflit d'intérêts
There are no conflicts of interest.