Clues to the Design of Aggregation-Resistant Insulin from Proline Scanning of Highly Amyloidogenic Peptides Derived from the N-Terminal Segment of the A-Chain.
A-chain
amyloid
insulin aggregation
insulin receptor
proline scan
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
25 Mar 2024
25 Mar 2024
Historique:
medline:
25
3
2024
pubmed:
25
3
2024
entrez:
25
3
2024
Statut:
aheadofprint
Résumé
Insulin aggregation poses a significant problem in pharmacology and medicine as it occurs during prolonged storage of the hormone and
Identifiants
pubmed: 38525800
doi: 10.1021/acs.molpharmaceut.4c00077
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM