Folate and vitamin B
Malawi
folate
neural tube defects
nonpregnant women
vitamin B12
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
05
02
2024
received:
03
10
2023
accepted:
19
02
2024
medline:
25
3
2024
pubmed:
25
3
2024
entrez:
25
3
2024
Statut:
ppublish
Résumé
Maternal folate and vitamin B We assessed folate and vitamin B Using data from the cross-sectional, nationally representative 2015-2016 Malawi Micronutrient Survey, we calculated the proportion of folate and vitamin B Among WRA, 8.5% (95% CI: 6.2, 11.6) and 13.3% (10.0, 17.4) had serum (<7 nmol/L) and RBC folate (<305 nmol/L) deficiency, respectively. The proportion of vitamin B These findings highlight the importance of nutritional and NTD surveillance in Malawi and the opportunity for improving folate and vitamin B
Sections du résumé
BACKGROUND
BACKGROUND
Maternal folate and vitamin B
OBJECTIVE
OBJECTIVE
We assessed folate and vitamin B
METHODS
METHODS
Using data from the cross-sectional, nationally representative 2015-2016 Malawi Micronutrient Survey, we calculated the proportion of folate and vitamin B
RESULTS
RESULTS
Among WRA, 8.5% (95% CI: 6.2, 11.6) and 13.3% (10.0, 17.4) had serum (<7 nmol/L) and RBC folate (<305 nmol/L) deficiency, respectively. The proportion of vitamin B
CONCLUSIONS
CONCLUSIONS
These findings highlight the importance of nutritional and NTD surveillance in Malawi and the opportunity for improving folate and vitamin B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2329Informations de copyright
© 2024 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Références
Allen, L. H. (2009). How common is vitamin B‐12 deficiency? The American Journal of Clinical Nutrition, 89(2), 693S–699S. https://doi.org/10.3945/ajcn.2008.26947A
Allen, L. H., Miller, J. W., de Groot, L., Rosenberg, I. H., Smith, A. D., Refsum, H., & Raiten, D. J. (2018). Biomarkers of nutrition for development (BOND): Vitamin B‐12 review. The Journal of Nutrition, 148(Suppl 4), 1995S–2027S. https://doi.org/10.1093/jn/nxy201
Becquey, E., & Martin‐Prevel, Y. (2010). Micronutrient adequacy of women's diet in urban Burkina Faso is low. The Journal of Nutrition, 140(11), 2079S–2085S. https://doi.org/10.3945/jn.110.123356
Berry, R. J., Li, Z., Erickson, J. D., Li, S., Moore, C. A., Wang, H., Mulinare, J., Zhao, P., Wong, L. Y. C., Gindler, J., Hong, S. X., Hao, L., Gunter, E., & Correa, A. (1999). Prevention of neural‐tube defects with folic acid in China. China–U.S. collaborative project for neural tube defect prevention. The New England Journal of Medicine, 341(20), 1485–1490. https://doi.org/10.1056/NEJM199911113412001
Black, M. M. (2008). Effects of vitamin B12 and folate deficiency on brain development in children. Food and Nutrition Bulletin, 29(2 Suppl), S126–S131. https://doi.org/10.1177/15648265080292S117
Bukowski, R., Malone, F. D., Porter, F. T., Nyberg, D. A., Comstock, C. H., Hankins, G. D., Eddleman, K., Gross, S. J., Dugoff, L., Craigo, S. D., Timor‐Tritsch, I. E., Carr, S. R., Wolfe, H. M., & D'Alton, M. E. (2009). Preconceptional folate supplementation and the risk of spontaneous preterm birth: A cohort study. PLoS Medicine, 6(5), e1000061. https://doi.org/10.1371/journal.pmed.1000061
Chapweteka, B. (2020). Evaluating the impact of mandatory folic acid fortification programme on the prevalence of spina bifida in southern region of Malawi: A central hospital based secondary data study. College of Medicine, University of Malawi. Retrieved September 30, 2023, from http://nkhokwe.kuhes.ac.mw/bitstream/handle/20.500.12845/633/Blessings%20Chapweteka‐MPH%20Thesis‐Approved%20copy_20032022.pdf?sequence=1&isAllowed=y
Crider, K. S., Bailey, L. B., & Berry, R. J. (2011). Folic acid food fortification‐its history, effect, concerns, and future directions. Nutrients, 3(3), 370–384. https://doi.org/10.3390/nu3030370
Crider, K. S., Devine, O., Hao, L., Dowling, N. F., Li, S., Molloy, A. M., Li, Z., Zhu, J., & Berry, R. J. (2014). Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ, 349, g4554. https://doi.org/10.1136/bmj.g4554
Crider, K. S., Qi, Y. P., Devine, O., Tinker, S. C., & Berry, R. J. (2018). Modeling the impact of folic acid fortification and supplementation on red blood cell folate concentrations and predicted neural tube defect risk in the United States: Have we reached optimal prevention? The American Journal of Clinical Nutrition, 107(6), 1027–1034. https://doi.org/10.1093/ajcn/nqy065
Czeizel, A. E., & Dudas, I. (1992). Prevention of the first occurrence of neural‐tube defects by periconceptional vitamin supplementation. The New England Journal of Medicine, 327(26), 1832–1835. https://doi.org/10.1056/NEJM199212243272602
De‐Regil, L. M., Pena‐Rosas, J. P., Fernandez‐Gaxiola, A. C., & Rayco‐Solon, P. (2015). Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database of Systematic Reviews, (12), CD007950. https://doi.org/10.1002/14651858.CD007950.pub3
Finkelstein, J. L., Fothergill, A., Johnson, C. B., Guetterman, H. M., Bose, B., Jabbar, S., Zhang, M., Pfeiffer, C. M., Qi, Y. P., Rose, C. E., Williams, J. L., Bonam, W., & Crider, K. S. (2021). Anemia and vitamin B‐12 and folate status in women of reproductive age in southern India: Estimating population‐based risk of neural tube defects. Current Developments in Nutrition, 5(5), nzab069. https://doi.org/10.1093/cdn/nzab069
Finkelstein, J. L., Layden, A. J., & Stover, P. J. (2015). Vitamin B‐12 and perinatal health. Advances in Nutrition, 6(5), 552–663. https://doi.org/10.3945/an.115.008201
Food Fortification Initiative. (2023). Country profile: Malawi. Retrieved September 30, 2023, from https://www.ffinetwork.org/malawi/?record=130
Gernand, A. D., Schulze, K. J., Stewart, C. P., West, K. P., Jr., & Christian, P. (2016). Micronutrient deficiencies in pregnancy worldwide: Health effects and prevention. Nature Reviews. Endocrinology, 12(5), 274–289. https://doi.org/10.1038/nrendo.2016.37
Global Fortification Data Exchange. (2023). Malawi fortification dashboard. Retrieved September 30, 2023, from https://fortificationdata.org/country‐fortification‐dashboard/?alpha3_code=MWI&dashboardPage=overview&lang=en
Hogeveen, M., Blom, H. J., & den Heijer, M. (2012). Maternal homocysteine and small‐for‐gestational‐age offspring: Systematic review and meta‐analysis. The American Journal of Clinical Nutrition, 95(1), 130–136. https://doi.org/10.3945/ajcn.111.016212
Hubner, U., Alwan, A., Jouma, M., Tabbaa, M., Schorr, H., & Herrmann, W. (2008). Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women. Clinical Chemistry and Laboratory Medicine, 46(9), 1265–1269. https://doi.org/10.1515/CCLM.2008.247
Mai, C. T., Isenburg, J. L., Canfield, M. A., Meyer, R. E., Correa, A., Alverson, C. J., Lupo, P. J., Riehle‐Colarusso, T., Cho, S. J., Aggarwal, D., Kirby, R. S., & National Birth Defects Prevention Network. (2019). National population‐based estimates for major birth defects, 2010–2014. Birth Defects Research, 111(18), 1420–1435. https://doi.org/10.1002/bdr2.1589
Mildon, A., Klaas, N., O'Leary, M., & Yiannakis, M. (2015). Can fortification be implemented in rural African communities where micronutrient deficiencies are greatest? Lessons from projects in Malawi, Tanzania, and Senegal. Food and Nutrition Bulletin, 36(1), 3–13. https://doi.org/10.1177/156482651503600101
Molloy, A. M. (2018). Should vitamin B12 status be considered in assessing risk of neural tube defects? Annals of the new York Academy of Sciences, 1414(1), 109–125. https://doi.org/10.1111/nyas.13574
Molloy, A. M., Kirke, P. N., Troendle, J. F., Burke, H., Sutton, M., Brody, L. C., Scott, J. M., & Mills, J. L. (2009). Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics, 123(3), 917–923. https://doi.org/10.1542/peds.2008-1173
MRC Vitamin Study Research Group. (1991). Prevention of neural tube defects: Results of the Medical Research Council vitamin study. Lancet, 338(8760), 131–137.
Msamati, B. C., Igbigbi, P. S., & Chisi, J. E. (2000). The incidence of cleft lip, cleft palate, hydrocephalus and spina bifida at Queen Elizabeth Central Hospital, Blantyre, Malawi. Central African Journal of Medicine, 46(11), 292–296. https://doi.org/10.4314/cajm.v46i11.8572
Muthayya, S., Kurpad, A. V., Duggan, C. P., Bosch, R. J., Dwarkanath, P., Mhaskar, A., Mhaskar, R., Thomas, A., Vaz, M., Bhat, S., & Fawzi, W. W. (2006). Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban south Indians. European Journal of Clinical Nutrition, 60(6), 791–801. https://doi.org/10.1038/sj.ejcn.1602383
National Statistical Office (NSO). (2017). Community Health Sciences Unit (CHSU) [Malawi], Centers for Disease Control and Prevention (CDC), and Emory University. Malawi Micronutrient Survey 2015–16. Atlanta, GA, USA: NSO, CHSU, CDC and Emory University. Retrieved September 16, 2022, from https://dhsprogram.com/pubs/pdf/FR319/FR319.m.final.pdf
National Statistical Office (NSO) [Malawi] and ICF. (2017). Malawi demographic and health survey 2015–16. NSO and ICF. Retrieved October 10, 2022, from https://dhsprogram.com/pubs/pdf/FR319/FR319.pdf
Nyirenda, E. (2017). Folate and vitamin B12 status among non‐pregnant women of reproductive age in Malawi. [Conference presentation]. IUNS 21st international congress of nutrition Buenos Aires, Argentina, October 15–20.
Obare, L. A., Esther, E., Ong'elleh, H., & Mutambi, F. (2017). Assessment of consumption monitoring systems fortified and nutritious foods in the east, central, and southern Africa (ECSA) region—final report. Nairobi, Kenya: Global Alliance for improved nutrition (GAIN). Retrieved September 16, 2022, from https://www.gainhealth.org/resources/reports‐and‐publications/assessment‐consumption‐monitoring‐systems‐fortified‐and
Pachón, H. (2021). Wheat flour fortification and human health. Burleigh Dodds Series in Agricultural Science. Burleigh Dodds Science Publishing.
Patrick, T. E., Powers, R. W., Daftary, A. R., Ness, R. B., & Roberts, J. M. (2004). Homocysteine and folic acid are inversely related in black women with preeclampsia. Hypertension, 43(6), 1279–1282. https://doi.org/10.1161/01.HYP.0000126580.81230.da
Pepper, M. R., & Black, M. M. (2011). B12 in fetal development. Seminars in Cell & Developmental Biology, 22(6), 619–623. https://doi.org/10.1016/j.semcdb.2011.05.005
Pfeiffer, C. M., Sternberg, M. R., Hamner, H. C., Crider, K. S., Lacher, D. A., Rogers, L. M., Bailey, R. L., & Yetley, E. A. (2016). Applying inappropriate cutoffs leads to misinterpretation of folate status in the US population. The American Journal of Clinical Nutrition, 104(6), 1607–1615. https://doi.org/10.3945/ajcn.116.138529
Pfeiffer, C. M., Zhang, M., Lacher, D. A., Molloy, A. M., Tamura, T., Yetley, E. A., Picciano, M. F., & Johnson, C. L. (2011). Comparison of serum and red blood cell folate microbiologic assays for national population surveys. The Journal of Nutrition, 141(7), 1402–1409. https://doi.org/10.3945/jn.111.141515
Ray, J. G., Wyatt, P. R., Thompson, M. D., Vermeulen, M. J., Meier, C., Wong, P. Y., Farrell, S. A., & Cole, D. E. C. (2007). Vitamin B12 and the risk of neural tube defects in a folic‐acid‐fortified population. Epidemiology, 18(3), 362–366. https://doi.org/10.1097/01.ede.0000257063.77411.e9
Relton, C. L., Pearce, M. S., & Parker, L. (2005). The influence of erythrocyte folate and serum vitamin B12 status on birth weight. The British Journal of Nutrition, 93(5), 593–599. https://doi.org/10.1079/bjn20041395
Reznikoff‐Etievant, M. F., Zittoun, J., Vaylet, C., Pernet, P., & Milliez, J. (2002). Low vitamin B(12) level as a risk factor for very early recurrent abortion. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 104(2), 156–159. https://doi.org/10.1016/s0301-2115(02)00100-8
Rhodes, E. C., Suchdev, P. S., Narayan, K. M. V., Cunningham, S., Weber, M. B., Tripp, K., Mapango, C., Ramakrishnan, U., Hennink, M., & Williams, A. M. (2020). The co‐occurrence of overweight and micronutrient deficiencies or anemia among women of reproductive age in Malawi. The Journal of Nutrition, 150(6), 1554–1565. https://doi.org/10.1093/jn/nxaa076
Rosenthal, J., Reeve, M. E., Ramirez, N., Crider, K. S., Sniezek, J., Vellozzi, C., Devine, O., & Lopez‐Pazos, E. (2016). Red blood cell folate insufficiency among nonpregnant women of childbearing age in Guatemala 2009 to 2010: Prevalence and predicted neural tube defects risk. Birth Defects Research. Part A, Clinical and Molecular Teratology, 106(7), 587–595. https://doi.org/10.1002/bdra.23499
Rowland, A. S., Baird, D. D., Shore, D. L., Weinberg, C. R., Savitz, D. A., & Wilcox, A. J. (1995). Nitrous oxide and spontaneous abortion in female dental assistants. American Journal of Epidemiology, 141(6), 531–538. https://doi.org/10.1093/oxfordjournals.aje.a117468
Sanku Project Healthy Children. (2015). Food fortification standards are officially mandatory in Malawi. Retrieved September 16, 2022, from https://projecthealthychildren.org/food‐fortification‐standards‐are‐officially‐mandatory‐in‐malawi/#:~:text=The%20publication%20and%20public%20announcement,and%20sugar%20throughout%20the%20country
Scholl, T. O., & Johnson, W. G. (2000). Folic acid: Influence on the outcome of pregnancy. The American Journal of Clinical Nutrition, 71(5 Suppl), 1295S–1303S. https://doi.org/10.1093/ajcn/71.5.1295s
Smithells, R. W., Sheppard, S., & Schorah, C. J. (1976). Vitamin deficiencies and neural tube defects. Archives of Disease in Childhood, 51(12), 944–950. https://doi.org/10.1136/adc.51.12.944
Tamura, T., & Picciano, M. F. (2006). Folate and human reproduction. The American Journal of Clinical Nutrition, 83(5), 993–1016. https://doi.org/10.1093/ajcn/83.5.993
Tang, K., Adams, K. P., Ferguson, E. L., Woldt, M., Kalimbira, A. A., Likoswe, B., Yourkavitch, J., Chrisinger, B., Pedersen, S., Segovia de la Revilla, L., Dary, O., Ander, E. L., & Joy, E. J. M. (2022). Modeling food fortification contributions to micronutrient requirements in Malawi using household consumption and expenditure surveys. Annals of the new York Academy of Sciences, 1508(1), 105–122. https://doi.org/10.1111/nyas.14697
Tinker, S. C., Hamner, H. C., Qi, Y. P., & Crider, K. S. (2015). U.S. women of childbearing age who are at possible increased risk of a neural tube defect‐affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Research. Part A, Clinical and Molecular Teratology, 103(6), 517–526. https://doi.org/10.1002/bdra.23378
Williams, J., Mai, C. T., Mulinare, J., Isenburg, J., Flood, T. J., Ethen, M., Frohnert, B., Kirby, R. S., & Centers for Disease Control and Prevention. (2015). Updated estimates of neural tube defects prevented by mandatory folic acid fortification—United States, 1995–2011. Morbidity and Mortality Weekly Report, 64(1), 1–5.
World Health Organization. (2015a). Serum and red blood cell folate concentrations for assessing folate status in populations. World Health Organization. Retrieved October 14, 2022, from https://www.who.int/publications/i/item/WHO-NMH-NHD-EPG-15.01
World Health Organization. (2015b). Guideline: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects. World Health Organization. Retrieved October 14, 2022, from https://www.who.int/publications/i/item/9789241549042