Do we Still Need Eligibility Criteria to Recommend PrEP? Impact of National Prescribing Requirements on Retention in Care and Sexually Transmitted Infections Acquisition.
PrEP
Prescribing criteria
Retention in care
Sexually transmitted infections
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
25 Mar 2024
25 Mar 2024
Historique:
accepted:
12
03
2024
medline:
25
3
2024
pubmed:
25
3
2024
entrez:
25
3
2024
Statut:
aheadofprint
Résumé
Italian guidelines recommend HIV pre-exposure prophylaxis (PrEP) only upon satisfying strict eligibility criteria. The objective of this study is to evaluate if PrEP candidates attending a community-based service comply with these criteria and whether these prescribing conditions affect retention in care and sexually transmitted infections (STIs) acquisition. A retrospective analysis was performed on PrEP candidates evaluated from January 2019 to June 2022. Data were collected from self-administered questionnaires and clinical files. The population was divided in subjects with 0/1 (0/1 C) and ≥ 2 (≥ 2 C) criteria. Descriptive statistics and non-parametric tests were employed to describe study population. Incidence of PrEP discontinuation and of STIs was estimated per 100 persons-year of follow up (PYFU), and incidence rate ratio (IRR) was calculated. Univariate and multivariable Cox regression analyses were used to evaluate the association strength between PrEP drop out and other variables. The analyses enrolled 659 individuals: 422 individuals were included in 0/1 C, 237 in ≥ 2 C group, respectively. Inconsistent condom use was the most reported prescribing criteria (399 individuals, 60.6%), followed by a previous STI (186 individuals, 28.2%). 0/1 C exhibited lower STIs incidence. PrEP discontinuation was 29% in 0/1 C and 38% in ≥ 2 C (p = 0.031). Cox model revealed that inconsistent condom use was the only prescribing criteria associated to PrEP persistence. The majority of PrEP candidate did not comply with prescribing conditions. Eligibility criteria failed to identify individuals with better retention in care. Our results suggest that Italian guidelines should be updated removing barriers to prescription.
Identifiants
pubmed: 38526636
doi: 10.1007/s10461-024-04320-3
pii: 10.1007/s10461-024-04320-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Collaborators GBD2019HIV. Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the global burden of diseases Study 2019. Lancet HIV. Oct. 2021;8(10):e633–51. https://doi.org/10.1016/S2352-3018(21)00152-1 .
Adams JL, Shelley K, Nicol MR. Review of Real-World Implementation Data on Emtricitabine-Tenofovir Disoproxil Fumarate as HIV Pre-exposure Prophylaxis in the United States, Pharmacotherapy, vol. 39, no. 4, pp. 486–500, Apr. 2019, https://doi.org/10.1002/phar.2240 .
ECDC. Country case studies: ECDC operational guidance on Pre-Exposure Prophylaxis (PrEP) in the EU/EEA and the UK. Stockholm: ECDC 2021. Accessed: Aug. 02, 2023. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/country-case-studies-ecdc-operational-guidance-prep .
SIMIT. Linee guida italiane sull’utilizzo della terapia antiretrovirale e la gestione diagnostico-clinica delle persone con infezione da HIV-1 — Edizione 2017. Accessed: Aug. 02, 2023. [Online]. Available: https://www.salute.gov.it/imgs/C_17_pubblicazioni_2696_allegato.pdf .
Rossotti R et al. Dec., Impact of COVID Pandemic on Sexual Habits and Pre-exposure Prophylaxis Retention in Care in a Community-Based Service, Sex. Res. Soc. Policy, vol. 20, no. 4, pp. 1592–1598, 2023, https://doi.org/10.1007/s13178-023-00849-5 .
Huang Y-LA, Tao G, Smith DK, Hoover KW. Persistence With Human Immunodeficiency Virus Pre-exposure Prophylaxis in the United States, 2012–2017, Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am, vol. 72, no. 3, pp. 379–385, Feb. 2021, https://doi.org/10.1093/cid/ciaa037 .
Chapin-Bardales J et al. HIV Pre-exposure Prophylaxis Persistence and Adherence Among Men Who Have Sex With Men in Four US Cities, J. Acquir. Immune Defic. Syndr 1999, vol. 93, no. 1, pp. 34–41, May 2023, https://doi.org/10.1097/QAI.0000000000003160 .
Reiriz M, Rodríguez-Expósito B, Jiménez-García AJ, Uceda S, Arias N. Pre-exposure Prophylaxis, anxiety, depression and sexual SatisfactionAmong men who have sex with men. Psicothema. May 2023;35(2):159–69. https://doi.org/10.7334/psicothema2022.230 .
Foster JM, Sanderman R, van der Molen T, Mueller T, van Sonderen E. Personality influences the reporting of side effects of inhaled corticosteroids in asthma patients, J. Asthma Off. J. Assoc. Care Asthma, vol. 45, no. 8, pp. 664–669, Oct. 2008, https://doi.org/10.1080/02770900802127022 .
Schnarrs PW et al. Sexual Subcultures and HIV Prevention Methods: An Assessment of Condom Use, PrEP, and TasP Among Gay, Bisexual, and Other Men Who Have Sex with Men Using a Social and Sexual Networking Smartphone Application, Arch. Sex. Behav, vol. 50, no. 4, pp. 1781–1792, May 2021, https://doi.org/10.1007/s10508-020-01784-x .
Grant RM, Koester KA. What people want from sex and preexposure prophylaxis. Curr Opin HIV AIDS. Jan. 2016;11(1):3–9. https://doi.org/10.1097/COH.0000000000000216 .
and the California Collaborative Treatment Group (CCTG) et al. et al. Greater Levels of Self-Reported Adherence to Pre-Exposure Prophylaxis (PrEP) are Associated with Increased Condomless Sex Among Men Who Have Sex with Men, AIDS Behav, vol. 24, no. 11, pp. 3192–3204, Nov. 2020, https://doi.org/10.1007/s10461-020-02881-7 .
Curley CM, Rosen AO, Mistler CB, Eaton LA. Pleasure and PrEP: A Systematic Review of Studies Examining Pleasure, Sexual Satisfaction, and PrEP, J. Sex Res, vol. 59, no. 7, pp. 848–861, Sep. 2022, https://doi.org/10.1080/00224499.2021.2012638 .
Mabire X, et al. Pleasure and PrEP: pleasure-seeking plays a role in Prevention choices and could lead to PrEP initiation. Am J Mens Health. 2019;13(1):1557988319827396. https://doi.org/10.1177/1557988319827396 .
doi: 10.1177/1557988319827396
pubmed: 30819060
pmcid: 6440035
Burns PA, Hall CDX, Poteat T, Mena LA, Wong FY. Living While Black, Gay, and Poor: The Association of Race, Neighborhood Structural Disadvantage, and PrEP Utilization Among a Sample of Black Men Who Have Sex With Men in the Deep South, AIDS Educ. Prev. Off. Publ. Int. Soc. AIDS Educ, vol. 33, no. 5, pp. 395–410, Oct. 2021, https://doi.org/10.1521/aeap.2021.33.5.395 .
Sullivan PS, et al. National trends in HIV pre-exposure prophylaxis awareness, willingness and use among United States men who have sex with men recruited online, 2013 through 2017. J Int AIDS Soc. Mar. 2020;23(3):e25461. https://doi.org/10.1002/jia2.25461 .
Organization WH. Guidance on oral pre-exposure prophylaxis (PrEP) for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV: recommendations for use in the context of demonstration projects. 2012. Jul. 01, 2012. Accessed: Aug. 05, 2023. [Online]. Available: https://www.who.int/publications/i/item/9789241503884 .