Evaluating and optimizing Acid-pH and Direct Lysis RNA extraction for SARS-CoV-2 RNA detection in whole saliva.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
25 Mar 2024
Historique:
received: 21 09 2023
accepted: 09 02 2024
medline: 26 3 2024
pubmed: 26 3 2024
entrez: 26 3 2024
Statut: epublish

Résumé

COVID-19 has been a global public health and economic challenge. Screening for the SARS-CoV-2 virus has been a key part of disease mitigation while the world continues to move forward, and lessons learned will benefit disease detection beyond COVID-19. Saliva specimen collection offers a less invasive, time- and cost-effective alternative to standard nasopharyngeal swabs. We optimized two different methods of saliva sample processing for RT-qPCR testing. Two methods were optimized to provide two cost-efficient ways to do testing for a minimum of four samples by pooling in a 2.0 mL tube and decrease the need for more highly trained personnel. Acid-pH-based RNA extraction method can be done without the need for expensive kits. Direct Lysis is a quick one-step reaction that can be applied quickly. Our optimized Acid-pH and Direct Lysis protocols are reliable and reproducible, detecting the beta-2 microglobulin (B2M) mRNA in saliva as an internal control from 97 to 96.7% of samples, respectively. The cycle threshold (Ct) values for B2M were significantly higher in the Direct Lysis protocol than in the Acid-pH protocol. The limit of detection for N1 gene was higher in Direct Lysis at ≤ 5 copies/μL than Acid-pH. Saliva samples collected over the course of several days from two COVID-positive individuals demonstrated Ct values for N1 that were consistently higher from Direct Lysis compared to Acid-pH. Collectively, this work supports that each of these techniques can be used to screen for SARS-CoV-2 in saliva for a cost-effective screening platform.

Identifiants

pubmed: 38527999
doi: 10.1038/s41598-024-54183-w
pii: 10.1038/s41598-024-54183-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7017

Subventions

Organisme : CIHR
ID : 177776
Pays : Canada

Informations de copyright

© 2024. Crown.

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Auteurs

Brayden LaBute (B)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Jackie Fong (J)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.
WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada.

Farinaz Ziaee (F)

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.

Robert Gombar (R)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Mathew Stover (M)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Terry Beaudin (T)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Maria Badalova (M)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Qiudi Geng (Q)

Great Lakes Institute for Environmental Research, University of Windsor, Windsor, ON, Canada.

Ryland Corchis-Scott (R)

Great Lakes Institute for Environmental Research, University of Windsor, Windsor, ON, Canada.

Ana Podadera (A)

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.

Kyle Lago (K)

WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada.

ZhenHuan Xu (Z)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Fievel Lim (F)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Felix Chiu (F)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Minghua Fu (M)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Xiaofeng Nie (X)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Yuanmin Wu (Y)

Aumintec Research Inc., Richmond Hill, ON, Canada.

Corrina Quan (C)

Windsor Regional Hospital, Windsor, ON, Canada.

Caroline Hamm (C)

WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada.
Windsor Regional Hospital, Windsor, ON, Canada.

R Michael McKay (RM)

Great Lakes Institute for Environmental Research, University of Windsor, Windsor, ON, Canada.

Kenneth Ng (K)

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.
WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada.

Lisa A Porter (LA)

Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada. lporter@uwindsor.ca.
WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada. lporter@uwindsor.ca.

Yufeng Tong (Y)

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada. Yufeng.Tong@uwindsor.ca.
WE-SPARK Health Institute, University of Windsor, Windsor, ON, Canada. Yufeng.Tong@uwindsor.ca.

Classifications MeSH