The evolutionary drivers and correlates of viral host jumps.
Journal
Nature ecology & evolution
ISSN: 2397-334X
Titre abrégé: Nat Ecol Evol
Pays: England
ID NLM: 101698577
Informations de publication
Date de publication:
25 Mar 2024
25 Mar 2024
Historique:
received:
11
01
2024
accepted:
29
01
2024
medline:
26
3
2024
pubmed:
26
3
2024
entrez:
26
3
2024
Statut:
aheadofprint
Résumé
Most emerging and re-emerging infectious diseases stem from viruses that naturally circulate in non-human vertebrates. When these viruses cross over into humans, they can cause disease outbreaks, epidemics and pandemics. While zoonotic host jumps have been extensively studied from an ecological perspective, little attention has gone into characterizing the evolutionary drivers and correlates underlying these events. To address this gap, we harnessed the entirety of publicly available viral genomic data, employing a comprehensive suite of network and phylogenetic analyses to investigate the evolutionary mechanisms underpinning recent viral host jumps. Surprisingly, we find that humans are as much a source as a sink for viral spillover events, insofar as we infer more viral host jumps from humans to other animals than from animals to humans. Moreover, we demonstrate heightened evolution in viral lineages that involve putative host jumps. We further observe that the extent of adaptation associated with a host jump is lower for viruses with broader host ranges. Finally, we show that the genomic targets of natural selection associated with host jumps vary across different viral families, with either structural or auxiliary genes being the prime targets of selection. Collectively, our results illuminate some of the evolutionary drivers underlying viral host jumps that may contribute to mitigating viral threats across species boundaries.
Identifiants
pubmed: 38528191
doi: 10.1038/s41559-024-02353-4
pii: 10.1038/s41559-024-02353-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agency for Science, Technology and Research (A*STAR)
ID : A*STAR National Science Scholarship (NSS-PhD)
Organisme : European Commission (EC)
ID : Horizon 2021-2024, END-VOC Project
Organisme : European Commission (EC)
ID : Horizon 2021-2024, END-VOC Project
Organisme : University College London (UCL)
ID : UCL Excellence Fellowship
Informations de copyright
© 2024. The Author(s).
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