The Contributions of Thrombospondin-1 to Epilepsy Formation.
Epileptogenesis
Hyperexcitability
Synaptogenesis
Thrombospondin-1
Journal
Neuroscience bulletin
ISSN: 1995-8218
Titre abrégé: Neurosci Bull
Pays: Singapore
ID NLM: 101256850
Informations de publication
Date de publication:
26 Mar 2024
26 Mar 2024
Historique:
received:
27
06
2023
accepted:
27
01
2024
medline:
26
3
2024
pubmed:
26
3
2024
entrez:
26
3
2024
Statut:
aheadofprint
Résumé
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca
Identifiants
pubmed: 38528256
doi: 10.1007/s12264-024-01194-2
pii: 10.1007/s12264-024-01194-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
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