Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI.
Brain trauma
Observational study
Post-traumatic headache
Secondary headache disorders
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
25 Mar 2024
25 Mar 2024
Historique:
received:
16
02
2024
accepted:
15
03
2024
medline:
26
3
2024
pubmed:
26
3
2024
entrez:
26
3
2024
Statut:
epublish
Résumé
Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. ClinicalTrials.gov NCT02210221.
Sections du résumé
BACKGROUND
BACKGROUND
Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury.
METHODS
METHODS
A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors.
RESULTS
RESULTS
A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury.
CONCLUSIONS
CONCLUSIONS
Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache.
TRIAL REGISTRATION
BACKGROUND
ClinicalTrials.gov NCT02210221.
Identifiants
pubmed: 38528477
doi: 10.1186/s10194-024-01751-0
pii: 10.1186/s10194-024-01751-0
doi:
Banques de données
ClinicalTrials.gov
['NCT02210221']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44Subventions
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Organisme : The European Union 7th Framework programme
ID : 602150
Investigateurs
Cecilia Åkerlund
(C)
Krisztina Amrein
(K)
Lasse Andreassen
(L)
Audny Anke
(A)
Anna Antoni
(A)
Gérard Audibert
(G)
Philippe Azouvi
(P)
Maria Luisa Azzolini
(ML)
Ronald Bartels
(R)
Pál Barzó
(P)
Romuald Beauvais
(R)
Ronny Beer
(R)
Bo-Michael Bellander
(BM)
Antonio Belli
(A)
Habib Benali
(H)
Maurizio Berardino
(M)
Luigi Beretta
(L)
Morten Blaabjerg
(M)
Peter Bragge
(P)
Alexandra Brazinova
(A)
Vibeke Brinck
(V)
Joanne Brooker
(J)
Camilla Brorsson
(C)
Andras Buki
(A)
Monika Bullinger
(M)
Manuel Cabeleira
(M)
Alessio Caccioppola
(A)
Emiliana Calappi
(E)
Maria Rosa Calv
(MR)
Peter Cameron
(P)
Guillermo Carbayo Lozano
(GC)
Marco Carbonara
(M)
Simona Cavallo
(S)
Giorgio Chevallard
(G)
Arturo Chieregato
(A)
Giuseppe Citerio
(G)
Hans Clusmann
(H)
Mark Coburn
(M)
Jonathan Coles
(J)
Jamie D Cooper
(JD)
Marta Correia
(M)
Amra Čović
(A)
Nicola Curry
(N)
Endre Czeiter
(E)
Marek Czosnyka
(M)
Claire Dahyot-Fizelier
(C)
Paul Dark
(P)
Helen Dawes
(H)
Véronique DeKeyser
(V)
Vincent Degos
(V)
Francesco Della Corte
(FD)
Hugo den Boogert
(HD)
Bart Depreitere
(B)
Đula Đilvesi
(Đ)
Abhishek Dixit
(A)
Emma Donoghue
(E)
Jens Dreier
(J)
Guy-Loup Dulière
(GL)
Ari Ercole
(A)
Patrick Esser
(P)
Erzsébet Ezer
(E)
Martin Fabricius
(M)
Valery L Feigin
(VL)
Kelly Foks
(K)
Shirin Frisvold
(S)
Alex Furmanov
(A)
Pablo Gagliardo
(P)
Damien Galanaud
(D)
Dashiell Gantner
(D)
Guoyi Gao
(G)
Pradeep George
(P)
Alexandre Ghuysen
(A)
Lelde Giga
(L)
Ben Glocker
(B)
Jagoš Golubovic
(J)
PedroA Gomez
(P)
Johannes Gratz Benjamin Gravesteijn
(JGB)
Francesca Grossi
(F)
RussellL Gruen
(R)
Deepak Gupta
(D)
JuanitaA Haagsma
(J)
Iain Haitsma
(I)
Raimund Helbok
(R)
Lindsay Horton
(L)
Jilske Huijben
(J)
PeterJ Hutchinson
(P)
Stefan Jankowski
(S)
Mike Jarrett
(M)
Ji-Yao Jiang
(JY)
Faye Johnson
(F)
Kelly Jones
(K)
Mladen Karan
(M)
AngelosG Kolias
(A)
Erwin Kompanje
(E)
Daniel Kondziella
(D)
Evgenios Kornaropoulos
(E)
Lars-Owe Koskinen
(LO)
Noémi Kovács
(N)
Ana Kowark
(A)
Alfonso Lagares
(A)
Linda Lanyon
(L)
Steven Laureys
(S)
Fiona Lecky
(F)
Didier Ledoux
(D)
Rolf Lefering
(R)
Valerie Legrand
(V)
Aurelie Lejeune
(A)
Leon Levi
(L)
Roger Lightfoot
(R)
Hester Lingsma
(H)
AndrewI R Maas
(AR)
Ana M Castaño-León
(AM)
Marc Maegele
(M)
Marek Majdan
(M)
Alex Manara
(A)
Geoffrey Manley
(G)
Costanza Martino
(C)
Hugues Maréchal
(H)
Julia Mattern
(J)
Catherine McMahon
(C)
Béla Melegh
(B)
David Menon
(D)
Tomas Menovsky
(T)
Ana Mikolic
(A)
Benoit Misset
(B)
Visakh Muraleedharan
(V)
Lynnette Murray
(L)
Ancuta Negru
(A)
David Nelson
(D)
Virginia Newcombe
(V)
Daan Nieboer
(D)
József Nyirádi
(J)
Otesile Olubukola
(O)
Matej Oresic
(M)
Fabrizio Ortolano
(F)
Aarno Palotie
(A)
Paul M Parizel
(PM)
Jean-François Payen
(JF)
Natascha Perera
(N)
Vincent Perlbarg
(V)
Paolo Persona
(P)
Wilco Peul
(W)
Anna Piippo-Karjalainen
(A)
Matti Pirinen
(M)
Dana Pisica
(D)
Horia Ples
(H)
Suzanne Polinder
(S)
Inigo Pomposo
(I)
Jussi P Posti
(JP)
Louis Puybasset
(L)
Andreea Radoi
(A)
Arminas Ragauskas
(A)
Rahul Raj
(R)
Malinka Rambadagalla
(M)
Isabel Retel Helmrich
(IR)
Jonathan Rhodes
(J)
Sylvia Richardson
(S)
Sophie Richter
(S)
Samuli Ripatti
(S)
Saulius Rocka
(S)
Olav Roise
(O)
Jonathan Rosand
(J)
Jeffrey V Rosenfeld
(JV)
Christina Rosenlund
(C)
Guy Rosenthal
(G)
Rolf Rossaint
(R)
Sandra Rossi
(S)
Daniel Rueckert Martin Rusnák
(DRM)
Juan Sahuquillo
(J)
Oliver Sakowitz
(O)
Renan Sanchez-Porras
(R)
Janos Sandor
(J)
Nadine Schäfer
(N)
Silke Schmidt
(S)
Herbert Schoechl
(H)
Guus Schoonman
(G)
Rico Frederik Schou
(RF)
Elisabeth Schwendenwein
(E)
Charlie Sewalt
(C)
Ranjit D Singh
(RD)
Peter Smielewski
(P)
Abayomi Sorinola
(A)
Emmanuel Stamatakis
(E)
Simon Stanworth
(S)
Robert Stevens
(R)
William Stewart
(W)
Ewout W Steyerberg
(EW)
Nino Stocchetti
(N)
Nina Sundström
(N)
Riikka Takala
(R)
Viktória Tamás
(V)
Tomas Tamosuitis
(T)
MarkSteven Taylor
(M)
Aurore Thibaut
(A)
Braden Te Ao
(BT)
Olli Tenovuo
(O)
Matt Thomas
(M)
Dick Tibboel
(D)
Marjolein Timmers
(M)
Christos Tolias
(C)
Tony Trapani
(T)
CristinaMaria Tudora
(C)
Andreas Unterberg
(A)
Peter Vajkoczy
(P)
Shirley Vallance
(S)
Egils Valeinis
(E)
Zoltán Vámos
(Z)
Mathieu van der Jagt
(M)
Gregory Van der Steen
(G)
Jeroen T J M van Dijck
(JTJM)
Inge A M van Erp
(IAM)
Thomas A van Essen
(TA)
Wim VanHecke
(W)
Caroline van Heugten
(C)
Ernest van Veen
(E)
Thijs Vande Vyvere
(TV)
Roel P J van Wijk
(RPJ)
Alessia Vargiolu
(A)
Emmanuel Vega
(E)
Kimberley Velt
(K)
Jan Verheyden
(J)
Paul M Vespa
(PM)
Anne Vik
(A)
Rimantas Vilcinis
(R)
Victor Volovici
(V)
Daphne Voormolen
(D)
Petar Vulekovic
(P)
KevinK W Wang
(KW)
Daniel Whitehouse
(D)
Eveline Wiegers
(E)
Guy Williams
(G)
Lindsay Wilson
(L)
Stefan Winzeck
(S)
Stefan Wolf
(S)
Zhihui Yang
(Z)
Peter Ylén
(P)
Frederick A Zeiler
(FA)
Veronika Zelinkova
(V)
Agate Ziverte
(A)
None TommasoZoerle
Informations de copyright
© 2024. The Author(s).
Références
Dikmen S, Machamer J, Fann JR, Temkin NR (2010) Rates of symptom reporting following traumatic brain injury. J Int Neuropsychol Soc 16(3):401–411
pubmed: 20188017
doi: 10.1017/S1355617710000196
Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders. Cephalalgia 38(1):1–211
Lucas S, Hoffman JM, Bell KR, Dikmen S (2014) A prospective study of prevalence and characterization of headache following mild traumatic brain injury. Cephalalgia 34(2):93–102
pubmed: 23921798
doi: 10.1177/0333102413499645
Defrin R (2014) Chronic post-traumatic headache: clinical findings and possible mechanisms. J Man Manip Ther 22(1):36–44
pubmed: 24976746
pmcid: 4062350
doi: 10.1179/2042618613Y.0000000053
Hoffman JM, Lucas S, Dikmen S, Braden CA, Brown AW, Brunner R et al (2011) Natural history of headache after traumatic brain injury. J Neurotrauma 28(9):1719–1725
pubmed: 21732765
pmcid: 3172878
doi: 10.1089/neu.2011.1914
Ashina H, Dodick DW, Barber J, Temkin NR, Chong CD, Adler JS et al (2023) Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study. Mayo Clin Proc 98(10):1515–1526
pubmed: 37480909
doi: 10.1016/j.mayocp.2023.02.026
Couch JR, Bearss C (2001) Chronic daily headache in the posttrauma syndrome: relation to extent of head injury. Headache 41(6):559–564
pubmed: 11437891
doi: 10.1046/j.1526-4610.2001.041006559.x
Nampiaparampil DE (2008) Prevalence of chronic pain after traumatic brain injury: a systematic review. JAMA 300(6):711–719
pubmed: 18698069
doi: 10.1001/jama.300.6.711
Nordhaug LH, Hagen K, Vik A, Stovner LJ, Follestad T, Pedersen T et al (2018) Headache following head injury: a population-based longitudinal cohort study (HUNT). J Headache Pain 19(1):8
pubmed: 29356960
pmcid: 5777966
doi: 10.1186/s10194-018-0838-2
Walker WC, Seel RT, Curtiss G, Warden DL (2005) Headache after moderate and severe traumatic brain injury: a longitudinal analysis. Arch Phys Med Rehabil 86(9):1793–1800
pubmed: 16181945
doi: 10.1016/j.apmr.2004.12.042
Nordhaug LH, Linde M, Follestad T, Skandsen ØN, Bjarkø VV, Skandsen T, Vik A (2019) Change in Headache Suffering and Predictors of Headache after Mild Traumatic Brain Injury: A Population-Based, Controlled, Longitudinal Study with Twelve-Month Follow-Up. J Neurotrauma 36(23):3244–3252
pubmed: 31195890
pmcid: 6857461
doi: 10.1089/neu.2018.6328
Flynn S, Moore B, van der Merwe AJ, Moses A, Lo J, Shahim P, Chan L (2023) Headaches in Traumatic Brain Injury: Improvement Over Time, Associations With Quality of Life, and Impact of Migraine-Type Headaches. J Head Trauma Rehabil 38(2):E109–E117
pubmed: 35666575
doi: 10.1097/HTR.0000000000000790
Hong CK, Joo JY, Shim YS, Sim SY, Kwon MA, Kim YB, Chung J (2017) The course of headache in patients with moderate-to-severe headache due to mild traumatic brain injury: a retrospective cross-sectional study. J Headache Pain 18(1):48
pubmed: 28429236
pmcid: 5398969
doi: 10.1186/s10194-017-0755-9
Walker WC, Marwitz JH, Wilk AR, Ketchum JM, Hoffman JM, Brown AW, Lucas S (2013) Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. Cephalalgia 33(12):998–1008
pubmed: 23575819
doi: 10.1177/0333102413482197
Voormolen DC, Haagsma JA, Polinder S, Maas AIR, Steyerberg EW, Vuleković P, et al. Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study. Journal of clinical medicine. 2019;8(11).
Yilmaz T, Roks G, de Koning M, Scheenen M, van der Horn H, Plas G et al (2017) Risk factors and outcomes associated with post-traumatic headache after mild traumatic brain injury. Emerg Med J 34(12):800–805
pubmed: 28689194
doi: 10.1136/emermed-2015-205429
Nestvold K, Lundar T, Mowinckel P, Stavem K (2005) Predictors of headache 22 years after hospitalization for head injury. Acta Neurol Scand 112(1):13–18
pubmed: 15932350
doi: 10.1111/j.1600-0404.2005.00344.x
Bomyea J, Lang AJ, Delano-Wood L, Jak A, Hanson KL, Sorg S et al (2016) Neuropsychiatric Predictors of Post-Injury Headache After Mild-Moderate Traumatic Brain Injury in Veterans. Headache 56(4):699–710
pubmed: 27028095
doi: 10.1111/head.12799
Chan TLH, Woldeamanuel YW (2020) Exploring naturally occurring clinical subgroups of post-traumatic headache. J Headache Pain 21(1):12
pubmed: 32033526
pmcid: 7006085
doi: 10.1186/s10194-020-1080-2
Ashina H, Al-Khazali HM, Iljazi A, Ashina S, Amin FM, Lipton RB, Schytz HW (2021) Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain 22(1):83
pubmed: 34311696
pmcid: 8314480
doi: 10.1186/s10194-021-01287-7
Ashina H, Iljazi A, Amin FM, Ashina M, Lipton RB, Schytz HW (2020) Interrelations between migraine-like headache and persistent post-traumatic headache attributed to mild traumatic brain injury: a prospective diary study. J Headache Pain 21(1):134
pubmed: 33213358
pmcid: 7678268
doi: 10.1186/s10194-020-01202-6
Quaid PT, Singman EL (2022) Post-traumatic headaches and vision: A review. NeuroRehabilitation 50(3):297–308
pubmed: 35367973
doi: 10.3233/NRE-228013
Calhoun AH, Ford S, Millen C, Finkel AG, Truong Y, Nie Y (2010) The prevalence of neck pain in migraine. Headache 50(8):1273–1277
pubmed: 20100298
doi: 10.1111/j.1526-4610.2009.01608.x
Cohen SP, Kapoor SG, Nguyen C, Anderson-Barnes VC, Brown C, Schiffer D et al (2010) Neck pain during combat operations: an epidemiological study analyzing clinical and prognostic factors. Spine 35(7):758–763
pubmed: 20228712
doi: 10.1097/BRS.0b013e3181bb11a8
Lampl C, Rudolph M, Deligianni CI, Mitsikostas DD (2015) Neck pain in episodic migraine: premonitory symptom or part of the attack? J Headache Pain 16:566
pubmed: 26329488
doi: 10.1186/s10194-015-0566-9
Shahidi B, Bursch RW, Carmel JS, Carranza AC, Cooper KM, Lee JV et al (2021) Greater Severity and Functional Impact of Post-traumatic Headache in Veterans With Comorbid Neck Pain Following Traumatic Brain Injury. Mil Med 186(11–12):1207–1214
pubmed: 33306100
doi: 10.1093/milmed/usaa532
Ashina H, Eigenbrodt AK, Seifert T, Sinclair AJ, Scher AI, Schytz HW et al (2021) Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment. The Lancet Neurology 20(6):460–469
pubmed: 34022171
doi: 10.1016/S1474-4422(21)00094-6
Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT et al (2015) Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery 76(1):67–80
pubmed: 25525693
doi: 10.1227/NEU.0000000000000575
Teasdale G, Jennett B (1974) Assessment of coma and impaired consciousness. A practical scale Lancet 2(7872):81–84
pubmed: 4136544
Gennarelli TA, Wodzin E (2006) AIS 2005: a contemporary injury scale. Injury 37(12):1083–1091
pubmed: 17092503
doi: 10.1016/j.injury.2006.07.009
Baker SP, O’Neill B, Haddon W Jr, Long WB (1974) The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 14(3):187–196
pubmed: 4814394
doi: 10.1097/00005373-197403000-00001
Mayhew D, Mendonca V, Murthy BVS (2019) A review of ASA physical status - historical perspectives and modern developments. Anaesthesia 74(3):373–379
pubmed: 30648259
doi: 10.1111/anae.14569
King NS, Crawford S, Wenden FJ, Moss NE, Wade DT (1995) The Rivermead Post Concussion Symptoms Questionnaire: a measure of symptoms commonly experienced after head injury and its reliability. J Neurol 242(9):587–592
pubmed: 8551320
doi: 10.1007/BF00868811
Balalla S, Krägeloh C, Medvedev O, Siegert R (2020) Is the Rivermead Post-Concussion Symptoms Questionnaire a Reliable and Valid Measure to Assess Long-Term Symptoms in Traumatic Brain Injury and Orthopedic Injury Patients? A Novel Investigation Using Rasch Analysis. Neurotrauma Rep 1(1):63–72
pubmed: 34223531
pmcid: 8240882
doi: 10.1089/neur.2020.0017
Lannsjo M, Borg J, Bjorklund G, Af Geijerstam JL, Lundgren-Nilsson A (2011) Internal construct validity of the Rivermead Post-Concussion Symptoms Questionnaire. Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine 43(11):997–1002
doi: 10.2340/16501977-0875
Crichton A, Anderson V, Oakley E, Greenham M, Hearps S, Delzoppo C et al (2018) Fatigue Following Traumatic Brain Injury in Children and Adolescents: A Longitudinal Follow-Up 6 to 12 Months After Injury. J Head Trauma Rehabil 33(3):200–209
pubmed: 28926479
doi: 10.1097/HTR.0000000000000330
White IR, Royston P, Wood AM (2011) Multiple imputation using chained equations: Issues and guidance for practice. Stat Med 30(4):377–399
pubmed: 21225900
doi: 10.1002/sim.4067
van der Naalt J, Timmerman ME, de Koning ME, van der Horn HJ, Scheenen ME, Jacobs B et al (2017) Early predictors of outcome after mild traumatic brain injury (UPFRONT): an observational cohort study. The Lancet Neurology 16(7):532–540
pubmed: 28653646
doi: 10.1016/S1474-4422(17)30117-5
Lambru G, Benemei S, Andreou AP, Luciani M, Serafini G, van den Brink AM, Martelletti P (2021) Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine. Pain Ther 10(1):1–13
pubmed: 33247827
doi: 10.1007/s40122-020-00220-1
Lahz S, Bryant RA (1996) Incidence of chronic pain following traumatic brain injury. Arch Phys Med Rehabil 77(9):889–891
pubmed: 8822679
doi: 10.1016/S0003-9993(96)90275-0
Rosner J, de Andrade DC, Davis KD, Gustin SM, Kramer JLK, Seal RP, Finnerup NB (2023) Central neuropathic pain. Nat Rev Dis Primers 9(1):73
pubmed: 38129427
doi: 10.1038/s41572-023-00484-9
Coffman C, Reyes D, Hess MC, Giakas AM, Thiam M, Sico JJ et al (2022) Relationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review. Neurology 99(2):e187–e198
pubmed: 35470141
pmcid: 9280992
doi: 10.1212/WNL.0000000000200518
Shih PK, Chen JX, Yang WC, Muo CH, Wu SC (2022) Risk of Subsequent Migraines in Facial Fracture Patients: A Population-Based Cohort Study. Facial Plast Surg Aesthet Med 24(1):41–47
pubmed: 33103918
doi: 10.1089/fpsam.2020.0361
Molla YD, Alemu HT, Kassa SA, Gebrehana DA, Abera SA, Tebeje HE, Demise AG (2024) Magnitude of dural tear and its associated factors among patients with depressed skull fracture. Ann Med Surg (Lond) 86(1):133–138
pubmed: 38222756
doi: 10.1097/MS9.0000000000001541
Labastida-Ramírez A, Benemei S, Albanese M, D’Amico A, Grillo G, Grosu O et al (2020) Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence. J Headache Pain 21(1):55
pubmed: 32448142
pmcid: 7245945
doi: 10.1186/s10194-020-01122-5
Schwedt TJ, Chong CD, Peplinski J, Ross K, Berisha V (2017) Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure. J Headache Pain 18(1):87
pubmed: 28831776
pmcid: 5567584
doi: 10.1186/s10194-017-0796-0
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K et al (2018) Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci 21(9):1209–1217
pubmed: 30150661
pmcid: 6148759
doi: 10.1038/s41593-018-0213-2
Kuburas A, Russo AF (2023) Shared and independent roles of CGRP and PACAP in migraine pathophysiology. J Headache Pain 24(1):34
pubmed: 37009867
pmcid: 10069045
doi: 10.1186/s10194-023-01569-2
Edvinsson L, Grell AS, Warfvinge K (2020) Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion. J Mol Neurosci 70(6):930–944
pubmed: 32086679
pmcid: 7253526
doi: 10.1007/s12031-020-01493-z
Ashina H, Iljazi A, Al-Khazali HM, Christensen CE, Amin FM, Ashina M, Schytz HW (2020) Hypersensitivity to Calcitonin Gene-Related Peptide in Post-Traumatic Headache. Ann Neurol 88(6):1220–1228
pubmed: 32959458
doi: 10.1002/ana.25915
Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Amin FM, Burstein R, Ashina H (2023) Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial. Brain
Russo AF, Hay DL (2023) CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond. Physiol Rev 103(2):1565–1644
pubmed: 36454715
doi: 10.1152/physrev.00059.2021
Russell FA, King R, Smillie SJ, Kodji X, Brain SD (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev 94(4):1099–1142
pubmed: 25287861
pmcid: 4187032
doi: 10.1152/physrev.00034.2013
Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Burstein R, Ashina H (2023) Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia 43(11):3331024231210930
pubmed: 37917826
doi: 10.1177/03331024231210930
Sutton M, Chan V, Escobar M, Mollayeva T, Hu Z, Colantonio A (2019) Neck Injury Comorbidity in Concussion-Related Emergency Department Visits: A Population-Based Study of Sex Differences Across the Life Span. J Womens Health (Larchmt) 28(4):473–482
pubmed: 30592685
doi: 10.1089/jwh.2018.7282
Kennedy E, Quinn D, Chapple C, Tumilty S (2019) Can the Neck Contribute to Persistent Symptoms Post Concussion? A Prospective Descriptive Case Series. J Orthop Sports Phys Ther 49(11):845–854
pubmed: 31154952
doi: 10.2519/jospt.2019.8547
Côté P, Yu H, Shearer HM, Randhawa K, Wong JJ, Mior S et al (2019) Non-pharmacological management of persistent headaches associated with neck pain: A clinical practice guideline from the Ontario protocol for traffic injury management (OPTIMa) collaboration. Eur J Pain 23(6):1051–1070
pubmed: 30707486
doi: 10.1002/ejp.1374
Yalinay Dikmen P, Ozge A, Martelletti P (2023) The use of clinical scales and PROMs in headache disorders and migraine, summarizing their dissemination and operationalization. Heliyon 9(5):e16187
pubmed: 37251845
pmcid: 10220237
doi: 10.1016/j.heliyon.2023.e16187
Steiner TJ, Stovner LJ (2023) Global epidemiology of migraine and its implications for public health and health policy. Nat Rev Neurol 19(2):109–117
pubmed: 36693999
doi: 10.1038/s41582-022-00763-1