Clinico-epidemiological presentations and management of Nipah virus infection during the outbreak in Kozhikode district, Kerala state, India 2023.

Kerala‐India Nipah virus acute respiratory distress syndrome encephalitis outbreak secondary cases spillover

Journal

Journal of medical virology

ISSN: 1096-9071

Titre abrégé: J Med Virol

Pays: United States

ID NLM: 7705876

Informations de publication

Date de publication:
Mar 2024

Historique:

revised: 09 02 2024

received: 23 12 2023

accepted: 13 03 2024

medline: 26 3 2024

pubmed: 26 3 2024

entrez: 26 3 2024

Statut: ppublish

Résumé

India experienced its sixth Nipah virus (NiV) outbreak in September 2023 in the Kozhikode district of Kerala state. The NiV is primarily transmitted by spillover events from infected bats followed by human-to-human transmission. The clinical specimens were screened using real-time RT-PCR, and positive specimens were further characterized using next-generation sequencing. We describe here an in-depth clinical presentation and management of NiV-confirmed cases and outbreak containment activities. The current outbreak reported a total of six cases with two deaths, with a case fatality ratio of 33.33%. The cases had a mixed presentation of acute respiratory distress syndrome and encephalitis syndrome. Fever was a persistent presentation in all the cases. The Nipah viral RNA was detected in clinical specimens until the post-onset day of illness (POD) 14, with viral load in the range of 1.7-3.3 × 10

Identifiants

DOI: 10.1002/jmv.29559 PMID: 38529536

pubmed: 38529536

doi: 10.1002/jmv.29559

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e29559

Subventions

Organisme : Indian Council of Medical Research, New Delhi

ID : VIR/28/2020/ECD-1

Informations de copyright

Références

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