The je ne sais quoi of 5-methylcytosine in messenger RNA.
RNA modification
RNA processing
RNA stability
methyltransferase
protein synthesis
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
26 Mar 2024
26 Mar 2024
Historique:
received:
04
02
2024
accepted:
09
02
2024
medline:
27
3
2024
pubmed:
27
3
2024
entrez:
26
3
2024
Statut:
aheadofprint
Résumé
The potential presence of 5-methylcytosine as a sparse internal modification of mRNA was first raised in 1975 and a first map of the modification was also part of the epitranscriptomics 'big bang' in 2012. Since then, the evidence for its presence in mRNA has firmed up and initial insights have been gained into the molecular function and broader biological relevance of 5-methylcytosine when present in mRNA. Here, we summarise the status quo of the field, outline some of its current challenges and suggest how to address them in future work.
Identifiants
pubmed: 38531644
pii: rna.079982.124
doi: 10.1261/rna.079982.124
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Published by Cold Spring Harbor Laboratory Press for the RNA Society.