Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
26 Mar 2024
26 Mar 2024
Historique:
received:
27
06
2023
accepted:
07
03
2024
revised:
05
03
2024
medline:
27
3
2024
pubmed:
27
3
2024
entrez:
27
3
2024
Statut:
epublish
Résumé
Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues' magnetic susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume and magnetic susceptibility and determines specific differences in these measures among patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls (HCs). This was a cross-sectional study. Sex- and age- matched patients with MDD (n = 49), patients with schizophrenia (n = 24), and HCs (n = 50) were included. Magnetic resonance imaging was conducted using quantitative susceptibility mapping and T1-weighted imaging to measure subcortical susceptibility and volume. The acquired brain measurements were compared among groups using analyses of variance and post hoc comparisons. Finally, a general linear model examined the susceptibility-volume relationship. Significant group-level differences were found in the magnetic susceptibility of the nucleus accumbens and amygdala (p = 0.045). Post-hoc analyses indicated that the magnetic susceptibility of the nucleus accumbens and amygdala for the MDD group was significantly higher than that for the HC group (p = 0.0054, p = 0.0065, respectively). However, no significant differences in subcortical volume were found between the groups. The general linear model indicated a significant interaction between group and volume for the nucleus accumbens in MDD group but not schizophrenia or HC groups. This study showed susceptibility alterations in the nucleus accumbens and amygdala in MDD patients. A significant relationship was observed between subcortical susceptibility and volume in the MDD group's nucleus accumbens, which indicated abnormalities in myelination and the dopaminergic system related to iron deposition.
Identifiants
pubmed: 38531856
doi: 10.1038/s41398-024-02862-7
pii: 10.1038/s41398-024-02862-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
164Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP18H02755, JP21H02851, JP22H03002 and JP23H03877
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP18H02755
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP18dm0307001, JP18dm0307004, and JP19dm0207069
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP18dm0307001
Organisme : MEXT | Japan Science and Technology Agency (JST)
ID : JPMJMS2021
Organisme : Japan Society for the Promotion of Science London (JSPS London)
ID : JP22H03002
Informations de copyright
© 2024. The Author(s).
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