Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing.

Adolescents Cannabis Cognition Longitudinal Psychopathology Reward Processing fMRI

Journal

Psychopharmacology

ISSN: 1432-2072

Titre abrégé: Psychopharmacology (Berl)

Pays: Germany

ID NLM: 7608025

Informations de publication

Date de publication:
26 Mar 2024

Historique:

received: 17 01 2024

accepted: 11 03 2024

medline: 27 3 2024

pubmed: 27 3 2024

entrez: 27 3 2024

Statut: aheadofprint

Résumé

For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research suggests that mental health problems associated with cannabis use may result from its effect on reward brain circuit, emotional processes, and cognition. However, findings are mostly derived from correlational studies and inconsistent, particularly in adolescents. Using data from the IMAGEN study, participants (non-users, persistent users, abstinent users) were classified according to their cannabis use at 19 and 22 years-old. All participants were cannabis-naïve at baseline (14 years-old). Psychopathological symptoms, cognitive performance, and brain activity while performing a Monetary Incentive Delay task were used as predictors of substance use and to analyze group differences over time. Higher scores on conduct problems and lower on peer problems at 14 years-old (n = 318) predicted a greater likelihood of transitioning to cannabis use within 5 years. At 19 years of age, individuals who consistently engaged in low-frequency (i.e., light) cannabis use (n = 57) exhibited greater conduct problems and hyperactivity/inattention symptoms compared to non-users (n = 52) but did not differ in emotional symptoms, cognitive functioning, or brain activity during the MID task. At 22 years, those who used cannabis at both 19 and 22 years-old n = 17), but not individuals that had been abstinent for ≥ 1 month (n = 19), reported higher conduct problems than non-users (n = 17). Impairments in reward-related brain activity and cognitive functioning do not appear to precede or succeed cannabis use (i.e., weekly, or monthly use). Cannabis-naïve adolescents with conduct problems and more socially engaged with their peers may be at a greater risk for lighter yet persistent cannabis use in the future.

Identifiants

DOI: 10.1007/s00213-024-06575-z PMID: 38532040

pubmed: 38532040

doi: 10.1007/s00213-024-06575-z

pii: 10.1007/s00213-024-06575-z

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Fundação para a Ciência e Tecnologia (FCT)

ID : 2021.06791.BD

Investigateurs

Gareth J Barker (GJ)

Herve Lemaitre (H)

Sabina Millenet (S)

Lauren Robinson (L)

Jeanne M Winterer (JM)

Informations de copyright

Références

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