Evaluation of Fecal Inflammatory Biomarkers to Identify Bacterial Diarrhea Episodes: Systematic Review and Protocol for the Enterics for Global Health

Shigella diagnostic diarrhea inflammatory biomarker systematic review

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Mar 2024
Historique:
medline: 27 3 2024
pubmed: 27 3 2024
entrez: 27 3 2024
Statut: epublish

Résumé

The measurement of fecal inflammatory biomarkers among individuals presenting to care with diarrhea could improve the identification of bacterial diarrheal episodes that would benefit from antibiotic therapy. We reviewed prior literature in this area and describe our proposed methods to evaluate 4 biomarkers in the Enterics for Global Health (EFGH) We systematically reviewed studies since 1970 from PubMed and Embase that assessed the diagnostic characteristics of inflammatory biomarkers to identify bacterial diarrhea episodes. We extracted sensitivity and specificity and summarized the evidence by biomarker and diarrhea etiology. In EFGH, we propose using commercial enzyme-linked immunosorbent assays to test for myeloperoxidase, calprotectin, lipocalin-2, and hemoglobin in stored whole stool samples collected within 24 hours of enrollment from participants in the Bangladesh, Kenya, Malawi, Pakistan, Peru, and The Gambia sites. We will develop clinical prediction scores that incorporate the inflammatory biomarkers and evaluate their ability to identify Forty-nine studies that assessed fecal leukocytes (n = 39), red blood cells (n = 26), lactoferrin (n = 13), calprotectin (n = 8), and myeloperoxidase (n = 1) were included in the systematic review. Sensitivities were high for identifying Our evaluation of inflammatory biomarkers to distinguish diarrhea etiologies as determined by qPCR will provide an important addition to the prior literature, which was likely biased by the limited sensitivity of the gold standard diagnostics used. We will determine whether point-of-care biomarker tests could be a viable strategy to inform treatment decision making and increase appropriate targeting of antibiotic treatment to bacterial diarrhea episodes.

Sections du résumé

Background UNASSIGNED
The measurement of fecal inflammatory biomarkers among individuals presenting to care with diarrhea could improve the identification of bacterial diarrheal episodes that would benefit from antibiotic therapy. We reviewed prior literature in this area and describe our proposed methods to evaluate 4 biomarkers in the Enterics for Global Health (EFGH)
Methods UNASSIGNED
We systematically reviewed studies since 1970 from PubMed and Embase that assessed the diagnostic characteristics of inflammatory biomarkers to identify bacterial diarrhea episodes. We extracted sensitivity and specificity and summarized the evidence by biomarker and diarrhea etiology. In EFGH, we propose using commercial enzyme-linked immunosorbent assays to test for myeloperoxidase, calprotectin, lipocalin-2, and hemoglobin in stored whole stool samples collected within 24 hours of enrollment from participants in the Bangladesh, Kenya, Malawi, Pakistan, Peru, and The Gambia sites. We will develop clinical prediction scores that incorporate the inflammatory biomarkers and evaluate their ability to identify
Results UNASSIGNED
Forty-nine studies that assessed fecal leukocytes (n = 39), red blood cells (n = 26), lactoferrin (n = 13), calprotectin (n = 8), and myeloperoxidase (n = 1) were included in the systematic review. Sensitivities were high for identifying
Conclusions UNASSIGNED
Our evaluation of inflammatory biomarkers to distinguish diarrhea etiologies as determined by qPCR will provide an important addition to the prior literature, which was likely biased by the limited sensitivity of the gold standard diagnostics used. We will determine whether point-of-care biomarker tests could be a viable strategy to inform treatment decision making and increase appropriate targeting of antibiotic treatment to bacterial diarrhea episodes.

Identifiants

DOI: 10.1093/ofid/ofad652 PMID: 38532957 PMC: PMC10962755
pubmed: 38532957
doi: 10.1093/ofid/ofad652
pii: ofad652
pmc: PMC10962755
doi:

Types de publication

Journal Article

Langues

eng

Pagination

S65-S75

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. All authors: No reported conflicts.

Auteurs

Courtney Babb (C)

Department of Epidemiology, Emory University, Atlanta, Georgia, USA.

Henry Badji (H)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Md Taufiqur Rahman Bhuiyan (MTR)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Jennifer Cornick (J)

Institute of Infection, Veterinary and Ecological Sciences, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.
Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

Sonia Qureshi (S)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Catherine Sonye (C)

Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Wagner V Shapiama Lopez (WV)

Asociación Benéfica PRISMA, Iquitos, Peru.

Mehreen Adnan (M)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Hannah E Atlas (HE)

Department of Global Health, University of Washington, Seattle, Washington, USA.

Kehkashan Begum (K)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Stephanie A Brennhofer (SA)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Bubacarr E Ceesay (BE)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Abdoulie K Ceesay (AK)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Nigel A Cunliffe (NA)

Institute of Infection, Veterinary and Ecological Sciences, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.

Paul F Garcia Bardales (PF)

Asociación Benéfica PRISMA, Iquitos, Peru.

Shahinur Haque (S)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Bri'Anna Horne (B)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

M Jahangir Hossain (MJ)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Junaid Iqbal (J)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Md Taufiqul Islam (MT)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Sadia Islam (S)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Farhana Khanam (F)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Karen L Kotloff (KL)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Thandizo Malemia (T)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

Katia Manzanares Villanueva (K)

Asociación Benéfica PRISMA, Iquitos, Peru.

Gertrude Malola Million (GM)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

Vitumbiko Munthali (V)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

John Benjamin Ochieng (JB)

Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Billy Ogwel (B)

Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Maribel Paredes Olortegui (M)

Asociación Benéfica PRISMA, Iquitos, Peru.

Richard Omore (R)

Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Patricia B Pavlinac (PB)

Department of Global Health, University of Washington, Seattle, Washington, USA.

James A Platts-Mills (JA)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Khandra T Sears (KT)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Ousman Secka (O)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Sharon M Tennant (SM)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Pablo Peñataro Yori (P)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Mohammad Tahir Yousafzai (MT)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Khuzwayo C Jere (KC)

Institute of Infection, Veterinary and Ecological Sciences, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.
Malawi Liverpool Wellcome Programme, Blantyre, Malawi.
Department of Medical Laboratory Sciences, Kamuzu University of Health Sciences, School of Life Sciences and Health Professions, Blantyre, Malawi.

Margaret N Kosek (MN)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Stephen Munga (S)

Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Usman N Ikumapayi (UN)

Medical Research Council Unit The Gambia, London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Firdausi Qadri (F)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Farah Naz Qamar (FN)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Elizabeth T Rogawski McQuade (ET)

Department of Epidemiology, Emory University, Atlanta, Georgia, USA.

Classifications MeSH