Exploring Natural Immune Responses to

Shigella diarrhea dried blood spot immune response multiplex bead assay

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Mar 2024
Historique:
medline: 27 3 2024
pubmed: 27 3 2024
entrez: 27 3 2024
Statut: epublish

Résumé

Molecular diagnostics on human fecal samples have identified a larger burden of shigellosis than previously appreciated by culture. Evidence of fold changes in immunoglobulin G (IgG) to conserved and type-specific We will test dried blood spots collected at enrollment and 4 weeks later using bead-based immunoassays for IgG to invasion plasmid antigen B and type-specific lipopolysaccharide O-antigen for The integration of these assays into the EFGH study will help support PCR-based attribution of acute diarrhea to type-specific

Sections du résumé

Background UNASSIGNED
Molecular diagnostics on human fecal samples have identified a larger burden of shigellosis than previously appreciated by culture. Evidence of fold changes in immunoglobulin G (IgG) to conserved and type-specific
Methods UNASSIGNED
We will test dried blood spots collected at enrollment and 4 weeks later using bead-based immunoassays for IgG to invasion plasmid antigen B and type-specific lipopolysaccharide O-antigen for
Conclusions UNASSIGNED
The integration of these assays into the EFGH study will help support PCR-based attribution of acute diarrhea to type-specific

Identifiants

DOI: 10.1093/ofid/ofad650 PMID: 38532958 PMC: PMC10962721
pubmed: 38532958
doi: 10.1093/ofid/ofad650
pii: ofad650
pmc: PMC10962721
doi:

Types de publication

Journal Article

Langues

eng

Pagination

S58-S64

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Auteurs

Prisca Benedicto-Matambo (P)

School of Biomedical Sciences and Health Professions, Department of Medical Laboratory Sciences, Kamuzu University of Health Sciences, Blantyre, Malawi.
Malawi Liverpool Wellcome Programme, Blantyre, Malawi.
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Liverpool, UK.

Lindsay N Avolio (LN)

Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Henry Badji (H)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Rabab Batool (R)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Farhana Khanam (F)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Stephen Munga (S)

Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.

Milagritos D Tapia (MD)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Pablo Peñataro Yori (P)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Alex O Awuor (AO)

Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.

Bubacarr E Ceesay (BE)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Jennifer Cornick (J)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Liverpool, UK.

Nigel A Cunliffe (NA)

Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Liverpool, UK.

Paul F Garcia Bardales (PF)

Asociación Benéfica PRISMA, Iquitos, Peru.

Christopher D Heaney (CD)

Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Aneeta Hotwani (A)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Mahzabeen Ireen (M)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Md Taufiqul Islam (M)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Ousman Jallow (O)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Robert W Kaminski (RW)

Latham Biopharm Group, Massachusetts, USA.

Wagner V Shapiama Lopez (WV)

Asociación Benéfica PRISMA, Iquitos, Peru.

Victor Maiden (V)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

Usman Nurudeen Ikumapayi (UN)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Ruth Nyirenda (R)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.

John Benjamin Ochieng (JB)

Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.

Richard Omore (R)

Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.

Maribel Paredes Olortegui (M)

Asociación Benéfica PRISMA, Iquitos, Peru.

Patricia B Pavlinac (PB)

Department of Global Health, University of Washington, Seattle, Washington, USA.

Nora Pisanic (N)

Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Firdausi Qadri (F)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Sonia Qureshi (S)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Nazia Rahman (N)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Elizabeth T Rogawski McQuade (ET)

Department of Epidemiology, Emory University, Atlanta, Georgia, USA.

Francesca Schiaffino (F)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Faculty of Veterinary Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

Ousman Secka (O)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Catherine Sonye (C)

Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.

Shazia Sultana (S)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Drissa Timite (D)

Centre pour le Développement des Vaccins du Mali, Bamako, Mali.

Awa Traore (A)

Centre pour le Développement des Vaccins du Mali, Bamako, Mali.

Mohammad Tahir Yousafzai (MT)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Md Taufiqur Rahman Bhuiyan (M)

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

M Jahangir Hossain (M)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Khuzwayo C Jere (KC)

Malawi Liverpool Wellcome Programme, Blantyre, Malawi.
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Department of Clinical Infection, Microbiology and Immunology, Liverpool, UK.
School of Life Sciences & Health Professions, Department of Medical Laboratory Sciences, Kamuzu University of Health Sciences, Blantyre, Malawi.

Margaret N Kosek (MN)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Karen L Kotloff (KL)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Farah Naz Qamar (FN)

Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.

Samba O Sow (SO)

Centre pour le Développement des Vaccins du Mali, Bamako, Mali.

James A Platts-Mills (JA)

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
ORCID: 0000-0002-4956-0418

Classifications MeSH