Altered glycosylation in secreting cells of the gastric glands of aquaporin-4-deficient mice.
AQP4‐deficient mouse
gastric glands
glycopattern analysis
lectin histochemistry
Journal
Microscopy research and technique
ISSN: 1097-0029
Titre abrégé: Microsc Res Tech
Pays: United States
ID NLM: 9203012
Informations de publication
Date de publication:
27 Mar 2024
27 Mar 2024
Historique:
revised:
08
03
2024
received:
24
01
2024
accepted:
17
03
2024
medline:
27
3
2024
pubmed:
27
3
2024
entrez:
27
3
2024
Statut:
aheadofprint
Résumé
Aquaporins (AQPs) are important for water transport in the gastrointestinal tract. Changes in their expression and/or localization could cause in disorders and be used as therapeutic targets. Aquaporin-4 (AQP4) is expressed predominantly on the basolateral membrane of the parietal cells in the corpus of the murine gastric glands. Although the secretion of gastric juice is not affected in AQP4-deficient knockout, we evaluated by light microscopy whether the lack of AQP4 affects the glycopatterns of secreting gastric cells. Wild type (WT) and AQP4-deficient knockout mice (KO) were fed a standard diet ad libitum before sacrifice. Segments of stomach corpus were collected, fixed in buffered formalin, and embedded in paraffin wax. Sections, 5-μm thick, were analyzed by histochemical methods (Periodic acid-Schiff, Alcian Blue pH 2.5), and binding of lectins specific to GalNAc (SBA, DBA), Gal (PNA) GlcNAc (WGA, GSAII) mannose and/or glucose (ConA), and fucose (UEA-I, AAA, LTA). Immunohistochemical methods such as anti-Muc6 for neck cells and anti- β- H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grants AFOSR (Air Force Office of Scientific Research) Multiscale characterization of collective astrocyte dynamics (AstroColl)
ID : FA9550-21-1-00352
Organisme : Grant AFOSR (Air Force Office of Scientific Research) Decoding astrocyte natural rhythms: Impact of actin and channel protein-dynamics across scales (ASTRODYN)
ID : FA95501910370
Organisme : European Commission Marie Skłodowska-Curie Actions -ITN-2020 ASTROTECH (GA956325)
ID : R21NS116892-01
Organisme : Grants AFOSR (Air Force Office of Scientific Research) Stochastic Biophysical Interactions within Aquaporin-4 Assemblies
ID : FA95502010324
Organisme : Grant NIH (National Institute of Health): AQP4 isoforms and brain edema
ID : R21NS116892
Organisme : University of Bari Aldo Moro: HORIZON EUROPE SEEDS INTERGLIO
ID : S081
Informations de copyright
© 2024 Wiley Periodicals LLC.
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