OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion.

CP: Cell biology CP: Metabolism Ca(2+) OSBP beta cell endoplasmic reticulum insulin membrane contact sites pH phophatidylinositol 4-phosphate secretory granule

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 Mar 2024
Historique:
received: 04 10 2023
revised: 07 02 2024
accepted: 07 03 2024
medline: 27 3 2024
pubmed: 27 3 2024
entrez: 27 3 2024
Statut: aheadofprint

Résumé

Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contacts with the endoplasmic reticulum and that the lipid exchange protein oxysterol-binding protein (OSBP) is recruited to these sites in a Ca

Identifiants

DOI: 10.1016/j.celrep.2024.113992 PMID: 38536815
pubmed: 38536815
pii: S2211-1247(24)00320-6
doi: 10.1016/j.celrep.2024.113992
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113992

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Styliani Panagiotou (S)

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Kia Wee Tan (KW)

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Phuoc My Nguyen (PM)

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Andreas Müller (A)

Molecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.

Affiong Ika Oqua (AI)

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Alejandra Tomas (A)

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Anna Wendt (A)

Department of Clinical Sciences, Lund University, Lund, Sweden; Lund University Diabetes Center (LUDC), Lund, Sweden.

Lena Eliasson (L)

Department of Clinical Sciences, Lund University, Lund, Sweden; Lund University Diabetes Center (LUDC), Lund, Sweden.

Anders Tengholm (A)

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Michele Solimena (M)

Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Olof Idevall-Hagren (O)

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. Electronic address: olof.idevall@mcb.uu.se.

Classifications MeSH