A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children.
Journal
NPJ science of learning
ISSN: 2056-7936
Titre abrégé: NPJ Sci Learn
Pays: England
ID NLM: 101689142
Informations de publication
Date de publication:
27 Mar 2024
27 Mar 2024
Historique:
received:
10
11
2022
accepted:
26
02
2024
medline:
28
3
2024
pubmed:
28
3
2024
entrez:
28
3
2024
Statut:
epublish
Résumé
Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, and most genetic studies were performed on Europeans. There is a lack of genome-wide association studies (GWAS) on literacy phenotypes of Chinese as a native language and English as a second language (ESL) in a Chinese population. In this study, we conducted GWAS on 34 reading/language-related phenotypes in Hong Kong Chinese bilingual children (including both twins and singletons; total N = 1046). We performed association tests at the single-variant, gene, and pathway levels. In addition, we tested genetic overlap of these phenotypes with other neuropsychiatric disorders, as well as cognitive performance (CP) and educational attainment (EA) using polygenic risk score (PRS) analysis. Totally 5 independent loci (LD-clumped at r
Identifiants
pubmed: 38538593
doi: 10.1038/s41539-024-00229-7
pii: 10.1038/s41539-024-00229-7
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26Informations de copyright
© 2024. The Author(s).
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