Period of hospitalization and mortality in transferred versus non-transferred COVID-19 patients: results from Germany.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
28 Mar 2024
Historique:
received: 23 06 2023
accepted: 15 03 2024
medline: 28 3 2024
pubmed: 28 3 2024
entrez: 28 3 2024
Statut: epublish

Résumé

COVID-19 was a challenge for health-care systems worldwide, causing large numbers of hospitalizations and inter-hospital transfers. We studied whether transfer, as well as its reason, was associated with the duration of hospitalization in non-ICU and ICU patients. For this purpose, all patients hospitalized due to COVID-19 between August 1st and December 31st, 2021, in a network of hospitals in Southern Germany were comprehensively characterized regarding their clinical course, therapy, complications, transfers, reasons for transfer, involved levels of care, total period of hospitalization and in-hospital mortality, using univariate and multiple regression analyses. While mortality was not significantly associated with transfer, the period of hospitalization was. In non-ICU patients (n = 545), median (quartiles) time was 7.0 (4.0-11.0) in non-transferred (n = 458) and 18.0 (11.0-29.0) days in transferred (n = 87) patients (p < 0.001). In ICU patients (n = 100 transferred, n = 115 non-transferred) it was 12.0 (8.3-18.0) and 22.0 (15.0-34.0) days (p < 0.001). Beyond ECMO therapy (4.5%), reasons for transfer were medical (33.2%) or capacity (61.9%) reasons, with medical/capacity reasons in 32/49 of non-ICU and 21/74 of ICU patients. Thus, the transfer of COVID-19 patients between hospitals was associated with longer periods of hospitalization, corresponding to greater health care utilization, for which specific patient characteristics and clinical decisions played a role.

Identifiants

pubmed: 38538711
doi: 10.1038/s41598-024-57272-y
pii: 10.1038/s41598-024-57272-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7338

Informations de copyright

© 2024. The Author(s).

Références

DIVI Intensivregister. Accessed June 18, 2023. https://www.intensivregister.de/#/aktuelle-lage/zeitreihen
Epidemiologisches Bulletin 24/2023. . Juni. Published online 2023.
Römmele, C. et al. Bettenkapazitätssteuerung in Zeiten der COVID-19-Pandemie. Anaesthesist. 69(10), 717–725. https://doi.org/10.1007/s00101-020-00830-6 (2020).
doi: 10.1007/s00101-020-00830-6 pubmed: 32821955 pmcid: 7441598
Communications E. intensiv. Accessed June 22, 2023. https://eref.thieme.de/ejournals/1439-3840_2020_03#/10.1055-a-1151-1089
Usher, M. G. et al. Responding to COVID-19 through interhospital resource coordination: A mixed-methods evaluation. J. Patient Saf. 18(4), 287–294. https://doi.org/10.1097/PTS.0000000000000916 (2022).
doi: 10.1097/PTS.0000000000000916 pubmed: 34569998
Bender, K. et al. Burden of hospital admissions and resulting patient interhospital transports during the 2020/2021 SARS-CoV-2 pandemic in Saxony, Germany. Sci. Rep. 13(1), 8407. https://doi.org/10.1038/s41598-023-35406-y (2023).
doi: 10.1038/s41598-023-35406-y pubmed: 37225747 pmcid: 10206557
Wortel, S. A. et al. Comparison of patient characteristics and long-term mortality between transferred and non-transferred COVID-19 patients in Dutch intensive care units: A national cohort study. Acta Anaesthesiol Scand. 66(9), 1107–1115. https://doi.org/10.1111/aas.14129 (2022).
doi: 10.1111/aas.14129 pubmed: 36031794 pmcid: 9539143
Sanchez, M. A. et al. Impact of ICU transfers on the mortality rate of patients with COVID-19: Insights from comprehensive national database in France. Ann. Intensive Care. 11(1), 151. https://doi.org/10.1186/s13613-021-00933-2 (2021).
doi: 10.1186/s13613-021-00933-2 pubmed: 34698966 pmcid: 8546754
Eiding, H., Kongsgaard, U. E., Olasveengen, T. M. & Heyerdahl, F. Interhospital transport of critically ill patients: A prospective observational study of patient and transport characteristics. Acta Anaesthesiol Scand. 66(2), 248–255. https://doi.org/10.1111/aas.14005 (2022).
doi: 10.1111/aas.14005 pubmed: 34811736
Horita, N. & Fukumoto, T. Global case fatality rate from COVID-19 has decreased by 96.8% during 2.5 years of the pandemic. J. Med. Virol. 95(1), e28231. https://doi.org/10.1002/jmv.28231 (2023).
doi: 10.1002/jmv.28231 pubmed: 36253938
Cini, C., Neto, A.S., Burrell, A., Udy, A., SPRINT-SARI Australia investigators. Inter-hospital transfer and clinical outcomes for people with COVID-19 admitted to intensive care units in Australia: an observational cohort study. Med. J. Aust. (2023). https://doi.org/10.5694/mja2.51917
Painvin, B. et al. Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France. Ann. Intensive Care. 11, 54. https://doi.org/10.1186/s13613-021-00841-5 (2021).
doi: 10.1186/s13613-021-00841-5 pubmed: 33788010 pmcid: 8011063
Chen, E. et al. Interhospital transfer outcomes for critically Ill patients with coronavirus disease 2019 requiring mechanical ventilation. Crit. Care Explor. 3(10), e0559. https://doi.org/10.1097/CCE.0000000000000559 (2021).
doi: 10.1097/CCE.0000000000000559 pubmed: 34729490 pmcid: 8553251
Budweiser, S., Baş, Ş., Jörres, R.A., et al. Comparison of the first and second waves of hospitalized patients with SARS-CoV-2. Dtsch Ärztebl Int. (2021). https://doi.org/10.3238/arztebl.m2021.0215
Budweiser, S. et al. Patients’ treatment limitations as predictive factor for mortality in COVID-19: Results from hospitalized patients of a hotspot region for SARS-CoV-2 infections. Respir Res. 22(1), 168. https://doi.org/10.1186/s12931-021-01756-2 (2021).
doi: 10.1186/s12931-021-01756-2 pubmed: 34098967 pmcid: 8182347
Malin, J. J. et al. Key summary of German national treatment guidance for hospitalized COVID-19 patients. Infection. 50(1), 93–106. https://doi.org/10.1007/s15010-021-01645-2 (2022).
doi: 10.1007/s15010-021-01645-2 pubmed: 34228347
Ärzteblatt DÄG Redaktion Deutsches. COVID-19-Intensivpatienten: Innerdeutsche Verlegungen. Deutsches Ärzteblatt. Published November 27, 2020. Accessed June 20, 2023. https://www.aerzteblatt.de/archiv/216919/COVID-19-Intensivpatienten-Innerdeutsche-Verlegungen
Krankenhäuser in Bayern. Bayerisches Staatsministerium für Gesundheit und Pflege. Accessed June 19, 2023. https://www.stmgp.bayern.de/gesundheitsversorgung/krankenhaeuser/krankenhaeuser-in-bayern/
Kurzeder, L. et al. A simple risk score for mortality including the PCR Ct value upon admission in patients hospitalized due to COVID-19. Infection. 50(5), 1155–1163. https://doi.org/10.1007/s15010-022-01783-1 (2022).
doi: 10.1007/s15010-022-01783-1 pubmed: 35218511 pmcid: 8881702
Godinjak, A. et al. Predictive value of SAPS II and APACHE II scoring systems for patient outcome in a medical intensive care unit. Acta Medica Acad. 45(2), 97–103. https://doi.org/10.5644/ama2006-124.165 (2016).
doi: 10.5644/ama2006-124.165
Ligtenberg, J. J. M. et al. Quality of interhospital transport of critically ill patients: a prospective audit. Crit. Care Lond Engl. 9(4), R446-451. https://doi.org/10.1186/cc3749 (2005).
doi: 10.1186/cc3749
Allen, R. et al. Interhospital transfer of critically Ill patients because of coronavirus disease 19-related respiratory failure. Air. Med. J. 39(6), 498–501. https://doi.org/10.1016/j.amj.2020.07.007 (2020).
doi: 10.1016/j.amj.2020.07.007 pubmed: 33228902 pmcid: 7381893
Huq, F. et al. Patient outcomes following transfer between intensive care units during the COVID -19 pandemic. Anaesthesia. 77(4), 398–404. https://doi.org/10.1111/anae.15680 (2022).
doi: 10.1111/anae.15680 pubmed: 35226964 pmcid: 9111416

Auteurs

Pascal Suski (P)

Department of Internal Medicine III, Division of Pneumology and Respiratory Medicine, RoMed Hospital Rosenheim, Ellmaierstraße 23, 83022, Rosenheim, Germany.

Rudolf A Jörres (RA)

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ziemssenstraße 1, 80336, Munich, Germany.

Sebastian Engelhardt (S)

Department of Emergency, RoMed Hospital Rosenheim, Ellmaierstraße 23, 83022, Rosenheim, Germany.

Kathrin Kahnert (K)

Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Marchioninistraße 15, 80336, Munich, Germany.
Pneumological Center, MediCenter Germering, Hartstraße 52, 82110, Munich, Germany.

Katharina Lenherr (K)

Department of Internal Medicine III, Division of Pneumology and Respiratory Medicine, RoMed Hospital Rosenheim, Ellmaierstraße 23, 83022, Rosenheim, Germany.

Andreas Bauer (A)

Institute for Anesthesiology and Surgical Intensive Care Medicine, RoMed Hospital Rosenheim, Ellmaierstraße 23, 83022, Rosenheim, Germany.

Stephan Budweiser (S)

Department of Internal Medicine III, Division of Pneumology and Respiratory Medicine, RoMed Hospital Rosenheim, Ellmaierstraße 23, 83022, Rosenheim, Germany. Stephan.budweiser@ro-med.de.
University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. Stephan.budweiser@ro-med.de.

Classifications MeSH