Multi-omics staging of locally advanced rectal cancer predicts treatment response: a pilot study.
Magnetic resonance imaging
Metabolomics
Multi-omics
Radiomics
Rectal cancer
Treatment response
Journal
La Radiologia medica
ISSN: 1826-6983
Titre abrégé: Radiol Med
Pays: Italy
ID NLM: 0177625
Informations de publication
Date de publication:
27 Mar 2024
27 Mar 2024
Historique:
received:
02
08
2023
accepted:
13
03
2024
medline:
28
3
2024
pubmed:
28
3
2024
entrez:
28
3
2024
Statut:
aheadofprint
Résumé
Treatment response assessment of rectal cancer patients is a critical component of personalized cancer care and it allows to identify suitable candidates for organ-preserving strategies. This pilot study employed a novel multi-omics approach combining MRI-based radiomic features and untargeted metabolomics to infer treatment response at staging. The metabolic signature highlighted how tumor cell viability is predictively down-regulated, while the response to oxidative stress was up-regulated in responder patients, showing significantly reduced oxoproline values at baseline compared to non-responder patients (p-value < 10
Identifiants
pubmed: 38538828
doi: 10.1007/s11547-024-01811-0
pii: 10.1007/s11547-024-01811-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
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