Structural and Dynamic Analyses of Pathogenic Variants in

PI3K PROS genomic data interpretation genomics overgrowth precision medicine undergrowth

Journal

Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444

Informations de publication

Date de publication:
23 Feb 2024
Historique:
received: 29 12 2023
revised: 15 02 2024
accepted: 19 02 2024
medline: 28 3 2024
pubmed: 28 3 2024
entrez: 28 3 2024
Statut: epublish

Résumé

The PI3K enzymes modify phospholipids to regulate cell growth and differentiation. Somatic variants in PI3K are recurrent in cancer and drive a proliferative phenotype. Somatic mosaicism of

Identifiants

DOI: 10.3390/life14030297 PMID: 38541623
pubmed: 38541623
pii: life14030297
doi: 10.3390/life14030297
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Nikita R Dsouza (NR)

Computational Structural Genomics Unit, Genomics Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Catherine E Cottrell (CE)

The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Department of Pathology, The Ohio State University, Columbus, OH 43210, USA.
ORCID: 0000-0002-2974-0235

Olivia M T Davies (OMT)

School of Medicine, Medical College of Wisconsin, Milwaukee, WI 53227, USA.

Megha M Tollefson (MM)

Department of Dermatology and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.

Ilona J Frieden (IJ)

Department of Dermatology, University of California-San Francisco, San Francisco, CA 94143, USA.

Donald Basel (D)

Division of Genetics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Raul Urrutia (R)

Computational Structural Genomics Unit, Genomics Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Beth A Drolet (BA)

Department of Dermatology Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.

Michael T Zimmermann (MT)

Computational Structural Genomics Unit, Genomics Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Clinical and Translational Sciences Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Classifications MeSH