Prostaglandin Transporter and Dipeptidyl Peptidase-4 as New Pharmacological Targets in the Prevention of Acute Kidney Injury in Diabetes: An In Vitro Study.
acute kidney injury
cyclo-oxygenase-2
diabetes mellitus
dipeptidyl peptidase-4
prostaglandin E2
prostaglandin transporter
proximal tubular cells
sepsis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
31
01
2024
revised:
27
02
2024
accepted:
12
03
2024
medline:
28
3
2024
pubmed:
28
3
2024
entrez:
28
3
2024
Statut:
epublish
Résumé
The probability of acute kidney injury (AKI) is higher in septic diabetic patients, which is associated with, among other factors, proximal tubular cell (PTC) injury induced by the hypoxic/hyperglycemic/inflammatory microenvironment that surrounds PTCs in these patients. Here, we exposed human PTCs (HK-2 cells) to 1% O
Identifiants
pubmed: 38542317
pii: ijms25063345
doi: 10.3390/ijms25063345
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund "A way to make Europe"
ID : REACT UE-CM2021-02
Organisme : Community of Madrid
ID : CIFRA_CORCM Ref: P2022/BMD7223