The Influence of High-Dose Parenteral Vitamin C on the Incidence and Severity of Postoperative Pulmonary Complications in Cardiac Surgery with Extracorporeal Circulation: A Randomized Controlled Trial.

ascorbic acid cardiac surgery extracorporeal circulation high-dose parenteral administration postoperative pulmonary complications vitamin C

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
07 Mar 2024
Historique:
received: 06 02 2024
revised: 04 03 2024
accepted: 05 03 2024
medline: 28 3 2024
pubmed: 28 3 2024
entrez: 28 3 2024
Statut: epublish

Résumé

Cardiac surgery (CS) with extracorporeal circulation (ECC), induces intense oxidative stress (OS) and systemic inflammatory response (SIR), which may seriously affect postoperative lung function. We aimed to test if high parenteral (200 mg/kg/24 h) daily doses of Vitamin C (VitC), given within 48 h after the beginning of the operation, may reduce the incidence and severity of postoperative pulmonary complications (PPCs) in CS patients. This single-center, prospective, randomized, single-blinded, interventional trial included 150 patients, assigned to control Group A (

Identifiants

DOI: 10.3390/nu16060761 PMID: 38542673
pubmed: 38542673
pii: nu16060761
doi: 10.3390/nu16060761
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Milica Karadžić Kočica (M)

Department of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.

Arsen Ristić (A)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Clinic for Cardiology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
ORCID: 0000-0002-0713-1180

Ivan Soldatović (I)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Department of Medical Statistics and Informatics, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
ORCID: 0000-0003-4893-1683

Dejan Lazović (D)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.

Jelena Čumić (J)

Department of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.

Miloš Grujić (M)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.

Radmila Karan (R)

Department of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
ORCID: 0000-0002-8713-4356

Duško Terzić (D)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.

Ivan Palibrk (I)

Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Department of Anesthesiology, Reanimatology and Intensive Care, Clinic for Abdominal Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.

Mladen Kočica (M)

Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
ORCID: 0000-0002-1391-5053

Dejan Marković (D)

Department of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
ORCID: 0000-0001-5167-4388

Classifications MeSH