Pathways from the superior colliculus and the nucleus of the optic tract to the posterior parietal cortex in macaque monkeys: Functional frameworks for representation updating and online movement guidance.

LIPv MIP MSTl non‐human primates systems neuroscience virus tracing

Journal

The European journal of neuroscience

ISSN: 1460-9568

Titre abrégé: Eur J Neurosci

Pays: France

ID NLM: 8918110

Informations de publication

Date de publication:
28 Mar 2024

Historique:

revised: 31 01 2024

received: 08 07 2023

accepted: 22 02 2024

medline: 28 3 2024

pubmed: 28 3 2024

entrez: 28 3 2024

Statut: aheadofprint

Résumé

The posterior parietal cortex (PPC) integrates multisensory and motor-related information for generating and updating body representations and movement plans. We used retrograde transneuronal transfer of rabies virus combined with a conventional tracer in macaque monkeys to identify direct and disynaptic pathways to the arm-related rostral medial intraparietal area (MIP), the ventral lateral intraparietal area (LIPv), belonging to the parietal eye field, and the pursuit-related lateral subdivision of the medial superior temporal area (MSTl). We found that these areas receive major disynaptic pathways via the thalamus from the nucleus of the optic tract (NOT) and the superior colliculus (SC), mainly ipsilaterally. NOT pathways, targeting MSTl most prominently, serve to process the sensory consequences of slow eye movements for which the NOT is the key sensorimotor interface. They potentially contribute to the directional asymmetry of the pursuit and optokinetic systems. MSTl and LIPv receive feedforward inputs from SC visual layers, which are potential correlates for fast detection of motion, perceptual saccadic suppression and visual spatial attention. MSTl is the target of efference copy pathways from saccade- and head-related compartments of SC motor layers and head-related reticulospinal neurons. They are potential sources of extraretinal signals related to eye and head movement in MSTl visual-tracking neurons. LIPv and rostral MIP receive efference copy pathways from all SC motor layers, providing online estimates of eye, head and arm movements. Our findings have important implications for understanding the role of the PPC in representation updating, internal models for online movement guidance, eye-hand coordination and optic ataxia.

Identifiants

DOI: 10.1111/ejn.16314 PMID: 38544445

pubmed: 38544445

doi: 10.1111/ejn.16314

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : European Union Grant EU 5th FP

ID : QLRT-2001-00151, EUROKINESIS

Organisme : Centre National de la Recherche Scientifique

Informations de copyright

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