Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors.
ADMET studies
heterocyclic compounds
molecular docking
pyridylpiperazine hybrid derivatives
urease inhibition
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2024
2024
Historique:
received:
16
01
2024
accepted:
23
02
2024
medline:
28
3
2024
pubmed:
28
3
2024
entrez:
28
3
2024
Statut:
epublish
Résumé
Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes a rise in pH, supports the survival of pathogens, and can lead to infections such as gastric disorders like ulcers and cancer in humans.
Identifiants
pubmed: 38545466
doi: 10.3389/fchem.2024.1371377
pii: 1371377
pmc: PMC10965793
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1371377Informations de copyright
Copyright © 2024 Akash, Zaib, Ahmad, Sultan and Al-Hussain.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.