MT: Delivery Strategies gene regulation miRNA delivery non-viral RNA vector trans-amplifying RNA trans-replication

Journal

Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621

Informations de publication

Date de publication:
11 Jun 2024
Historique:
received: 31 08 2023
accepted: 28 02 2024
medline: 28 3 2024
pubmed: 28 3 2024
entrez: 28 3 2024
Statut: epublish

Résumé

The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and

Identifiants

pubmed: 38545619
doi: 10.1016/j.omtn.2024.102162
pii: S2162-2531(24)00049-0
pmc: PMC10965815
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102162

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

U.S., T.B., and A.Y. are inventors on patents and patent applications that cover parts of this article. U.S. is a management board member and employee and has securities from BioNTech SE, a company developing therapeutic RNA.

Auteurs

Ayşegül Yıldız (A)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Aida Hasani (A)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Tina Hempel (T)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Nina Köhl (N)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Aline Beicht (A)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

René Becker (R)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Stefanie Hubich-Rau (S)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Martin Suchan (M)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Marco A Poleganov (MA)

BioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.

Ugur Sahin (U)

BioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.

Tim Beissert (T)

TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Freiligrathstrasse 12, 55131 Mainz, Germany.

Classifications MeSH