A complex immune communication between eicosanoids and pulmonary macrophages.
Journal
Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941
Informations de publication
Date de publication:
27 Mar 2024
27 Mar 2024
Historique:
received:
23
01
2024
revised:
28
02
2024
accepted:
29
02
2024
medline:
29
3
2024
pubmed:
29
3
2024
entrez:
28
3
2024
Statut:
aheadofprint
Résumé
Respiratory viral infections represent a constant threat for human health and urge for a better understanding of the pulmonary immune response to prevent disease severity. Macrophages are at the center of pulmonary immunity, where they play a pivotal role in orchestrating beneficial and/or pathological outcomes during infection. Eicosanoids, the host bioactive lipid mediators, have re-emerged as important regulators of pulmonary immunity during respiratory viral infections. In this review, we summarize the current knowledge linking eicosanoids' and pulmonary macrophages' homeostatic and antimicrobial functions and discuss eicosanoids as emerging targets for immunotherapy in viral infection.
Identifiants
pubmed: 38547562
pii: S1879-6257(24)00013-0
doi: 10.1016/j.coviro.2024.101399
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101399Informations de copyright
Copyright © 2024 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.