Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40-CD40L Linkage.

differentiation hepatocellular carcinoma interferon-gamma soluble immune checkpoint proteins

Journal

The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502

Informations de publication

Date de publication:
26 Mar 2024
Historique:
received: 04 01 2024
revised: 26 02 2024
accepted: 15 03 2024
medline: 29 3 2024
pubmed: 29 3 2024
entrez: 28 3 2024
Statut: aheadofprint

Résumé

Hepatocellular carcinoma (HCC) is associated with elevated soluble CD40 levels in our previous study. Here we aimed to investigate CD40's role in liver tumor progression. We examined CD40 levels in HCC patient tissues and various HCC cell lines, studying their interaction with CD4

Identifiants

DOI: 10.1016/j.ajpath.2024.03.004 PMID: 38548267
pubmed: 38548267
pii: S0002-9440(24)00117-2
doi: 10.1016/j.ajpath.2024.03.004
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Hanh Vinh Ngo (HV)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Thuy Thi Thanh Le (TT)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan; Department of Global Education and Medical Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Hieu Ngoc Vu (HN)

Department of Microbiology, Hanoi Medical University, Hanoi, Vietnam.

Hai Hoang (H)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Hiroko Ikenaga (H)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Misako Sato-Matsubara (M)

Department of Veterinary Science, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, Japan.

Sawako Uchida-Kobayashi (S)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Hayato Urushima (H)

Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Khanh Van Nguyen (KV)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan; Department of Pathology, VinMec International Hospital, Hanoi, Vietnam.

Ha Thi Nguyen (HT)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Hiroji Shinkawa (H)

Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Shoji Kubo (S)

Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Naoko Ohtani (N)

Department of Pathophysiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Masaru Enomoto (M)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Akihiro Tamori (A)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan; Department of Hepatology, Kashiwara Municipal Hospital, Osaka, Japan.

Norifumi Kawada (N)

Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. Electronic address: kawadanori@omu.ac.jp.

Classifications MeSH