Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.
CD163
PET
atherosclerosis
resident macrophages
targeting
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
28 Mar 2024
28 Mar 2024
Historique:
received:
23
10
2023
revised:
26
02
2024
medline:
29
3
2024
pubmed:
29
3
2024
entrez:
28
3
2024
Statut:
aheadofprint
Résumé
Tissue-resident macrophages are complementary to proinflammatory macrophages to promote the progression of atherosclerosis. The noninvasive detection of their presence and dynamic variation will be important to the understanding of their role in the pathogenesis of atherosclerosis. The goal of this study was to develop a targeted PET radiotracer for imaging CD163-positive (CD163+) macrophages in multiple mouse atherosclerosis models and assess the potential of CD163 as a biomarker for atherosclerosis in humans.
Identifiants
pubmed: 38548349
pii: jnumed.123.266910
doi: 10.2967/jnumed.123.266910
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.