Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase.

AChE BChE cholinesterase herbicid herbicide inhibicija inhibition kolinesteraza konstanta disocijacije neurotoksičnost neurotoxicity organofosforni spojevi organophosphorus compounds pesticide

Journal

Arhiv za higijenu rada i toksikologiju

ISSN: 1848-6312

Titre abrégé: Arh Hig Rada Toksikol

Pays: Croatia

ID NLM: 0373100

Informations de publication

Date de publication:
01 Mar 2024

Historique:

received: 01 01 2024

accepted: 01 03 2024

medline: 29 3 2024

pubmed: 29 3 2024

entrez: 28 3 2024

Statut: epublish

Résumé

Glyphosate has remained the leading herbicide on the global market to date, despite the continuous debate between consumers, scientific community, and regulatory agencies over its carcinogenicity, genotoxicity, environmental persistence, and the role in the development of neurodegenerative disorders. Chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes of the cholinergic system essential for maintaining neurotransmission. Although research shows that glyphosate is a weak cholinesterase inhibitor in fish and mammals compared to other OP compounds, no conclusive data exist concerning the inhibition of human AChE and BChE. In our study we analysed its inhibitory potency on human AChE and BChE, by establishing its IC Glifosat je vodeći herbicid na današnjem svjetskom tržištu, unatoč neprestanim raspravama između potrošača, znanstvene zajednice i regulatornih agencija o njegovoj kancerogenosti, genotoksičnosti, postojanosti u okolišu i utjecaju na razvoj neurodegenerativnih bolesti. Kemijski gledano, glifosat pripada velikoj obitelji pesticida, organofosfornim spojevima (OP) koji imaju neurotoksični učinak inhibirajući acetilkolinesterazu (AChE) i butirilkolinesterazu (BChE), esencijalne enzime kolinergičnoga sustava koji održava proces prijenosa živčanih impulsa. Iako su različita istraživanja pokazala da je glifosat slab inhibitor kolinesteraza u riba, sisavaca i ljudi u odnosu na druge organofosforne spojeve, još uvijek ne postoje konačni podatci o njegovoj inhibiciji ljudske AChE i BChE. U ovoj smo studiji analizirali inhibitorni potencijal za ljudsku AChE i BChE, procijenili IC

Autres résumés

Type: Publisher (hrv)

Glifosat je vodeći herbicid na današnjem svjetskom tržištu, unatoč neprestanim raspravama između potrošača, znanstvene zajednice i regulatornih agencija o njegovoj kancerogenosti, genotoksičnosti, postojanosti u okolišu i utjecaju na razvoj neurodegenerativnih bolesti. Kemijski gledano, glifosat pripada velikoj obitelji pesticida, organofosfornim spojevima (OP) koji imaju neurotoksični učinak inhibirajući acetilkolinesterazu (AChE) i butirilkolinesterazu (BChE), esencijalne enzime kolinergičnoga sustava koji održava proces prijenosa živčanih impulsa. Iako su različita istraživanja pokazala da je glifosat slab inhibitor kolinesteraza u riba, sisavaca i ljudi u odnosu na druge organofosforne spojeve, još uvijek ne postoje konačni podatci o njegovoj inhibiciji ljudske AChE i BChE. U ovoj smo studiji analizirali inhibitorni potencijal za ljudsku AChE i BChE, procijenili IC

Identifiants

DOI: 10.2478/aiht-2024-75-3822 PMID: 38548375

pubmed: 38548375

pii: aiht-2024-75-3822

doi: 10.2478/aiht-2024-75-3822

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

76-80

Informations de copyright

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