TCTP regulates genotoxic stress and tumorigenicity via intercellular vesicular signaling.
Bystander Effect
Signaling
Small Extracellular Vesicles (sEVs)
Tumor Reprogramming
Tumor Reversion
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
28 Mar 2024
28 Mar 2024
Historique:
received:
22
09
2023
accepted:
21
02
2024
revised:
04
02
2024
medline:
29
3
2024
pubmed:
29
3
2024
entrez:
29
3
2024
Statut:
aheadofprint
Résumé
Oncogenic intercellular signaling is regulated by extracellular vesicles (EVs), but the underlying mechanisms remain mostly unclear. Since TCTP (translationally controlled tumor protein) is an EV component, we investigated whether it has a role in genotoxic stress signaling and malignant transformation. By generating a Tctp-inducible knockout mouse model (Tctp
Identifiants
pubmed: 38548973
doi: 10.1038/s44319-024-00108-7
pii: 10.1038/s44319-024-00108-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Institut National Du Cancer (INCa)
ID : Projets libres 2013-1-PL BIO-10-IGR-1 « Biologie et Sciences du Cancer »
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR- 09-BLAN-0292
Informations de copyright
© 2024. The Author(s).
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