Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals.

The pathogenesis of chronic diabetes complications has oxidative stress as one of the major elements, and single-nucleotide polymorphisms (SNPs) in genes belonging to antioxidant pathways modulate susceptibility to these complications. Considering that melatonin is a powerful antioxidant compound, our aim was to explore, in a longitudinal cohort study of type 1 diabetes (T1D) individuals, the association of microvascular complications and SNPs in the gene encoding melatonin receptor 1A ( Eight SNPs in The group of individuals with a renal function decline ≥ 5 mL min This is the first study showing an association between a variant in a gene belonging to the melatonin system and renal function decline in the diabetic setting.

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Copyright © 2024 Daher, Santos-Bezerra, Cavaleiro, Pelaes, Admoni, Perez, Machado, Amaral, Cipolla-Neto and Correa-Giannella.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.