Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
29 Mar 2024
29 Mar 2024
Historique:
received:
03
08
2023
accepted:
12
03
2024
revised:
03
03
2024
medline:
30
3
2024
pubmed:
30
3
2024
entrez:
30
3
2024
Statut:
aheadofprint
Résumé
Recurrences of depressive episodes in major depressive disorder (MDD) can be explained by the diathesis-stress model, suggesting that stressful life events (SLEs) can trigger MDD episodes in individuals with pre-existing vulnerabilities. However, the longitudinal neurobiological impact of SLEs on gray matter volume (GMV) in MDD and its interaction with early-life adversity remains unresolved. In 754 participants aged 18-65 years (362 MDD patients; 392 healthy controls; HCs), we assessed longitudinal associations between SLEs (Life Events Questionnaire) and whole-brain GMV changes (3 Tesla MRI) during a 2-year interval, using voxel-based morphometry in SPM12/CAT12. We also explored the potential moderating role of childhood maltreatment (Childhood Trauma Questionnaire) on these associations. Over the 2-year interval, HCs demonstrated significant GMV reductions in the middle frontal, precentral, and postcentral gyri in response to higher levels of SLEs, while MDD patients showed no such GMV changes. Childhood maltreatment did not moderate these associations in either group. However, MDD patients who had at least one depressive episode during the 2-year interval, compared to those who did not, or HCs, showed GMV increases in the middle frontal, precentral, and postcentral gyri associated with an increase in SLEs and childhood maltreatment. Our findings indicate distinct GMV changes in response to SLEs between MDD patients and HCs. GMV decreases in HCs may represent adaptive responses to stress, whereas GMV increases in MDD patients with both childhood maltreatment and a depressive episode during the 2-year interval may indicate maladaptive changes, suggesting a neural foundation for the diathesis-stress model in MDD recurrences.
Identifiants
pubmed: 38553539
doi: 10.1038/s41380-024-02526-4
pii: 10.1038/s41380-024-02526-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : HA7070/2-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : JA1890/7-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : JA1890/7-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RE737/20-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RE737/20-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : STR1146/18-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KR3822/5-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KR3822/7-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : DA1151/5-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : DA1151/5-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KI588/14-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KI588/14-2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KI588/20-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : KI588/22-1
Informations de copyright
© 2024. The Author(s).
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